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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Examination of a second region of the HIV type 1 genome reveals additional cases of superinfection
AIDS Research and Human Retroviruses, Volume 24, No. 9, Year 2008
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Description
HIV-1 superinfection may occur at a rate similar to that of initial infection, raising concerns for HIV-1 vaccine strategies predicated on eliciting immune responses similar to those in natural infection. Because of the high rate of recombination during HIV-1 replication, studies examining only one region of the HIV-1 genome are likely to miss cases of HIV-1 superinfection. We examined HIV-1 gag sequences from 14 high-risk Kenyan women in whom superinfection was not detected in a previous study of env sequences. We detected two additional cases of HIV-1 superinfection: one intersubtype superinfection that occurred between 1046 and 1487 days postinfection (DPI) and one intrasubtype superinfection that occurred between 341 and 440 DPI. Our results suggest that studies that examine only small genome regions may lead to underestimates of the risk of superinfection, highlighting the need for more extensive studies examining multiple regions of the HIV-1 genome. © 2008 Mary Ann Liebert, Inc.
Authors & Co-Authors
Piantadosi, Anne L.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Ngayo, Musa Otieno
United States, Seattle
Fred Hutchinson Cancer Research Center
Kenya, Nairobi
Kenya Medical Research Institute
Chohan, Bhavna H.
United States, Seattle
Fred Hutchinson Cancer Research Center
Kenya, Nairobi
University of Nairobi
Overbaugh, Julie M.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Statistics
Citations: 50
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1089/aid.2008.0100
ISSN:
08892229
Research Areas
Infectious Diseases
Study Locations
Multi-countries
Participants Gender
Female