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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation
Proceedings of the National Academy of Sciences of the United States of America, Volume 104, No. 21, Year 2007
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Description
Null mutations in the IL1-receptor accessory protein-like 1 gene (IL1RAPL1) are responsible for an inherited X-linked form of cognitive impairment. IL1RAPL1 protein physically interacts with neuronal calcium sensor-1 (NCS-1), but the functional impact of the IL1RAPL1/NCS-1 interaction remains unknown. Here, we demonstrate that stable expression of IL1RAPL1 in PC12 cells induces a specific silencing of N-type voltage-gated calcium channels (N-VGCC) activity that explains a secretion deficit observed in these IL1RAPL1 cells. Importantly, this modulation of VGCC activity is mediated by NCS-1. Indeed, a specific loss-of-function of N-VGCC was observed in PC12 cells overexpressing NCS-1, and a total recovery of N-VGCC activity was obtained by a down-regulation of NCS-1 in IL1RAPL1 cells. The functional relevance of the interaction between IL1RAPL1 and NCS-1 was also suggested by the reduction of neurite elongation observed in nerve growth factor (NGF)-treated IL1RAPL1 cells, a phenotype rescued by NCS-1 inactivation. Because both proteins are highly expressed in neurons, these results suggest that IL1RAPL1-related mental retardation could result from a disruption of N-VGCC and/or NCS-1-dependent synaptic and neuronal activities. © 2007 by The National Academy of Sciences of the USA.
Authors & Co-Authors
Bahi, Nadia
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Inserm
Hadj Kacem, Hassen
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Inserm
Chelly, Jamel
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Inserm
Vitale, Nicolas
France, Strasbourg
Université de Strasbourg
Statistics
Citations: 86
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1073/pnas.0701133104
ISSN:
00278424
Research Areas
Genetics And Genomics