Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected black South Africans: A pilot study
AIDS Research and Human Retroviruses, Volume 29, No. 7, Year 2013
Notification
URL copied to clipboard!
Description
Studies suggest that mitochondrial DNA (mtDNA) haplogroups are associated with antiretroviral therapy (ART)-related metabolic complications and distal sensory polyneuropathy (DSP), but there have been few studies in persons of African descent. We explored such associations in South African adults. Clinical and laboratory data and DNA specimens from a cross-sectional study were used. Sequencing and Phylotree determined African mtDNA subhaplogroups. Wilcoxon and regression analyses determined associations between mtDNA subhaplogroups and ART-related complications. The 171 participants represented six major haplogroups: L0 (n=78), L1 (n=3), L2 (n=30), L3 (n=53), L4 (n=1), and L5 (n=6). Analyses were restricted to 161 participants representing L0, L2, and L3: 78% were female; the median age was 36 years. All had been exposed to thymidine analogues, 42% were on lopinavir/ritonavir (lopinavir/r), and 58% were on either efavirenz or nevirapine. Median (IQR) ART duration was 22 (14-36) months. Median fasting triglycerides were 1.60 (1.13-1.75) and 1.04 (0.83-1.45) mmol/liter among L3e1 (n=22) and other subhaplogroups, respectively (p=0.003). Subhaplogroup L3e1 [adjusted OR (aOR) 3.16 (95% CI: 1.11-8.96); p=0.03] and exposure to lopinavir/r [aOR 2.98 (95% CI: 1.02-8.96); p=0.05] were independently associated with hypertriglyceridemia, after adjusting for age, sex, and ART duration. There were no significant associations between mtDNA haplogroups and cholesterol, dysglycemia, hyperlactatemia, or lipoatrophy, or DSP. Subhaplogroup L3e1 and lopinavir/r exposure were independently associated with hypertriglyceridemia in black South Africans on ART. This is the first report to link an African mtDNA variant with hypertriglyceridemia. If replicated, these findings may provide new insights into host factors affecting metabolic complications. © 2013, Mary Ann Liebert, Inc.
Authors & Co-Authors
Sinxadi, Phumla Zuleika
South Africa, Cape Town
Faculty of Health Sciences
Dave, Joel A.
South Africa, Cape Town
Faculty of Health Sciences
Samuels, David C.
United States, Nashville
Vanderbilt University School of Medicine
Heckmann, Jeannine M.
South Africa, Cape Town
Faculty of Health Sciences
Maartens, Gary Tuberculosis
South Africa, Cape Town
Faculty of Health Sciences
Levitt, Naomi S.
South Africa, Cape Town
Faculty of Health Sciences
Wester, Carolyn William
United States, Nashville
Vanderbilt University School of Medicine
Haas, David William
United States, Nashville
Vanderbilt University School of Medicine
Hulgan, Todd
United States, Nashville
Vanderbilt University School of Medicine
Statistics
Citations: 20
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1089/aid.2012.0373
ISSN:
08892229
e-ISSN:
19318405
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Female