Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Fanconi's anemia-Chromosome breakage studies in homozygotes and heterozygotes
Cancer Genetics and Cytogenetics, Volume 33, No. 2, Year 1988
Notification
URL copied to clipboard!
Description
The in vitro enhancement of chromosome breakage by diepoxybutane (DEB) and mitomycin C (MMC) was studied in 24 Fanconi's anemia (FA) homozygotes and 28 heterozygotes. Both drugs were shown to enhance chromosome breakage significantly in the homozygotes. In the great majority of cases, DEB and MMC stressing are reliable techniques for the definitive cytogenetic diagnosis of FA homozygosity. However, the present study provides no evidence that individual FA heterozygotes can be differentiated from normal individuals on the basis of spontaneous, DEB- or MMC-induced chromosome breakage. © 1988.
Authors & Co-Authors
Rosendorff, Jennifer
South Africa, Johannesburg
School of Pathology
South Africa, Johannesburg
University of the Witwatersrand
Bernstein, Renée
South Africa, Johannesburg
School of Pathology
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 34
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/0165-4608(88)90027-1
ISSN:
01654608