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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Measuring quality of life in rural Uganda: Reliability and validity of summary scores from the Medical Outcomes Study HIV Health Survey (MOS-HIV)
Quality of Life Research, Volume 21, No. 9, Year 2012
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Description
Purpose Summary scores derived from the Medical Outcomes Study HIV Health Survey (MOS-HIV) are used to assess treatment impacts among HIV-infected patients in Western settings, but have yet to be validated in rural, African settings. We examined the reliability, validity and responsiveness of scores among a prospective cohort of 947 HIV-1-infected adults initiating antiretroviral therapy between May 2003 and May 2004 in rural Uganda. Methods Physical (PHS) and mental health (MHS) summary scores were developed from baseline MOS-HIV subdomains using exploratory factor analysis. Construct and discriminant validity were established by comparing mean summary scores across known groups of sociodemographic, clinical and health status characteristics. Effect sizes were calculated to assess responsiveness to therapy. Results Reliability of the PHS and MHS scores was 0.79 and 0.85, respectively. Mean baseline PHS and MHS scores varied significantly by CD4 cell count, HIV viral load, WHO stage of disease and Karnofsky performance status scores. By 12 months on antiretroviral therapy, PHS and MHS scores improved by 14.6 points (P<0.001) and 13.9 points (P<0.001), respectively. Conclusions PHS and MHS scores can be derived from the MOS-HIV and used to assess health status among cohorts of patients taking antiretroviral therapy in rural Uganda. © Springer Science+Business Media B.V. 2012.
Authors & Co-Authors
Stangl, Anne L.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
United States, Columbia
International Center for Research on Women
Uganda, Entebbe
Uganda Virus Research Institute
Bunnell, Rebecca E.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Wamai, Nafuna
Uganda, Entebbe
Uganda Virus Research Institute
Masaba, Humphrey
Uganda, Entebbe
Uganda Virus Research Institute
Mermin, Jonathan H.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Statistics
Citations: 55
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1007/s11136-011-0075-5
ISSN:
09629343
Research Areas
Disability
Infectious Diseases
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Exploratory Study
Study Approach
Quantitative
Study Locations
Uganda