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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Phylodynamics and Human-mediated dispersal of a zoonotic virus
PLoS Pathogens, Volume 6, No. 10, Article e1001166, Year 2010
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Description
Understanding the role of humans in the dispersal of predominately animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geopolitical boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that expected for RABV transmission in African dog populations. These results are strongly supportive of human-mediated dispersal, and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing, predicting, and potentially controlling the spatial spread of pathogens. © 2010 Talbi et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2965766/bin/ppat.1001166.s001.doc
Authors & Co-Authors
Talbi, Chiraz
France, Paris
Institut Pasteur, Paris
Lemey, Philippe
Belgium, Leuven
Rega Institute for Medical Research
Suchard, Marc A.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Abdelatif, Elbia
Algeria, Algiers
Institut Pasteur - Alger
El-Harrak, Mehdi
Morocco
Biopharma Laboratoire
Jalal, Nourlil
Morocco, Casablanca
Institut Pasteur du Maroc
Faouzi, Abdellah
Morocco, Casablanca
Institut Pasteur du Maroc
Echevarría, Juan E.
Spain, Madrid
Instituto de Salud Carlos Iii
Morón, Sonia Vazquez
Spain, Madrid
Instituto de Salud Carlos Iii
Rambaut, Andrew
United Kingdom, Edinburgh
The University of Edinburgh
United States, Bethesda
National Institutes of Health Nih
Campiz, Nicholas
United States, Gainesville
University of Florida
Tatem, Andrew J.
United States, Gainesville
University of Florida
Holmes, Edward C.
United States, Bethesda
National Institutes of Health Nih
United States, University Park
Pennsylvania State University
Bourhy, Hervé
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 14
Authors: 14
Affiliations: 11
Identifiers
Doi:
10.1371/journal.ppat.1001166
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries