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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Incidence and risk factors for hepatitis C infection in a cohort of women in rural Egypt
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 102, No. 9, Year 2008
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Description
A prospective cohort study of the incidence and risk factors for hepatitis C virus (HCV) infection was performed in 2171 pregnant women in three rural Egyptian villages who were HCV antibody (anti-HCV) and RNA (HCV-RNA) negative at baseline. During an average of 2.2 years follow up, 25 incident cases were observed, giving an estimated HCV incidence of 5.2/1000 person-years (PY). The infection rate correlated with community anti-HCV prevalence in pregnant women, while the perinatal incidence rate of 11.2/1000 PY was almost five times that of the non-perinatal rate (2.3/1000 PY). The data suggested iatrogenic perinatal risk factors were associated with infection in one village, while health education reduced infections in another. Among the 25 incident cases, eight were HCV-RNA negative when they were first found to be anti-HCV positive and one-third of the 15 viraemic cases with follow-up data available cleared their HCV-RNA after an average of 1.3 years. None of the 25 incident cases were jaundiced or had symptoms of hepatitis but elevated serum alanine aminotransferase levels confirmed hepatitis in nine. Our data suggest that asymptomatic HCV infections frequently occurred during the perinatal period but often cleared and that educating medical personnel on safe practices possibly reduced HCV transmission. © 2008.
Authors & Co-Authors
Saleh, Doa'a A.
Egypt, Cairo
Faculty of Medicine
Shebl, Fatma Mohamed
United States, Baltimore
University of Maryland School of Medicine
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Abdel-Hamid, Mohamed A.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Minya
Faculty of Medicine
Narooz, Shaker I.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
NNH Mikhail, Nabiel N.H.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
El-Batanony, Manal
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
A El-Kafrawy, Sherif Aly
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
El-Daly, Maï Mohamed
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Sharaf, Soraya A.
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Hashem, Mohamed S.
United States, Baltimore
University of Maryland School of Medicine
El-Kamary, Samer S.
United States, Baltimore
University of Maryland School of Medicine
Magder, Laurence S.
United States, Baltimore
University of Maryland School of Medicine
Stoszek, Sonia Karolina
United States, Baltimore
University of Maryland School of Medicine
Strickland, George Thomas
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 67
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1016/j.trstmh.2008.04.011
ISSN:
00359203
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Egypt
Participants Gender
Female