Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola
Malaria Journal, Volume 10, Article 248, Year 2011
Notification
URL copied to clipboard!
Description
Background: Plasmodium falciparum malaria remains a leading health problem in Africa and its control is seriously challenged by drug resistance. Although resistance to the sulphadoxine-pyrimethamine (SP) is widespread, this combination remains an important component of malaria control programmes as intermittent preventive therapy (IPT) for pregnant women and children. In Angola, resistance patterns have been poorly characterized, and IPT has been employed for pregnant women since 2006. The aim of this study was to assess the prevalence of key antifolate resistance mediating polymorphisms in the pfdhfr and pfdhps genes in P. falciparum samples from Angola. Methods. Plasmodium falciparum samples collected in Luanda, in 2007, were genotyped by amplification and DNA forward and reverse sequencing of the pfdhfr and pfdhps genes. Results: The most prevalent polymorphisms identified were pfdhfr 108N (100%), 51I (93%), 59R (57%) and pfdhps 437G (93%). Resistance-mediating polymorphisms in pfdhps less commonly observed in West Africa were also identified (540E in 10%, 581G in 7% of samples). Conclusion: This study documents an important prevalence of 4 P. falciparum polymorphisms that predicts an antifolate resistance in Luanda. Further, some samples presented additional mutations associated to high-level resistance. These results suggest that the use of SP for IPT may no longer be warranted in Angola. © 2011 Gama et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Gama, Bianca E.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Pereira-Carvalho, Guilhermina A.L.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Angola, Luanda
National Institute of Public Health
Lutucuta Kosi, Florbela J.I.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Angola, Luanda
University Agostinho Neto
Almeida De Oliveira, Natália K.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Fortes, Fabiane Silva A.
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Angola, Luanda
National Institute of Public Health
Rosenthal, Philip Jon
United States, San Francisco
Ucsf School of Medicine
do Rosário, Virgílio Estólio
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Daniel-Ribeiro, Cláudio Tadeu
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Ferreira-Da-Cruz, Maria De Fátima
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Statistics
Citations: 25
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1186/1475-2875-10-248
e-ISSN:
14752875
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Angola
Participants Gender
Female