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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Changes in some rat hepatic microsomal components induced by prolonged administration of chloroquine
Biochemical Pharmacology, Volume 32, No. 20, Year 1983
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Description
Alterations in microsomal drug metabolizing enzymes and phospholipids following prolonged exposure to chloroquine have been investigated. The levels of microsomal aminopyrine-N-demethylase, aniline hydroxylase and both microsomal and cytosolic glutathione-S-transferase are reduced in treated rats. Microsomal epoxide hydrolase is unaffected by the treatment. An increase in the cholesterol-phospholipid ratio and a decrease in the phosphocholine-sphingomyelin ratio occur. There is a general reduction in the total microsomal phospholipid level though the percentage content of sphingomyelin is higher in all cases. The reduction in microsomal phospholipid level is probably due to a reduced incorporation of acetate into microsomal phospholipids as shown in this study using radioactive sodium acetate. © 1983.
Authors & Co-Authors
Emerole, Godwin O.
Nigeria, Ibadan
University of Ibadan
Thabrew, Myrtle Ira
Nigeria, Ibadan
University of Ibadan
Statistics
Citations: 29
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1016/0006-2952(83)90241-1
ISSN:
00062952