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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Nature, Volume 496, No. 7446, Year 2013
Notification
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Description
Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details of their generation could provide a blueprint for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection. The mature antibody, CH103, neutralized approximately 55% of HIV-1 isolates, and its co-crystal structure with the HIV-1 envelope protein gp120 revealed a new loop-based mechanism of CD4-binding-site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the unmutated common ancestor of the CH103 lineage avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data determine the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies, and provide insights into strategies to elicit similar antibodies by vaccination. © 2013 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Liao, Huaxin
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Lynch, Rebecca M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Zhou, Tongqing
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Gao, Feng
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Alam, S. Munir
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Boyd, Scott D.
United States, Palo Alto
Stanford University
Fire, Andrew Z.
United States, Palo Alto
Stanford University
Roskin, Krishna M.
United States, Palo Alto
Stanford University
Schramm, Chaim A.
United States, New York
Columbia University
Zhang, Zhenhai
United States, New York
Columbia University
Zhu, Jiang
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Shapiro, Lawrence S.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, New York
Columbia University
Mullikin, James C.
United States, Bethesda
National Institutes of Health Nih
United States, Bethesda
National Human Genome Research Institute Nhgri
Gnanakaran, Sandrasegaram
United States, Los Alamos
Los Alamos National Laboratory Theoretical Division
Hraber, Peter T.
United States, Los Alamos
Los Alamos National Laboratory Theoretical Division
Wiehe, Kevin J.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Kelsoe, Garnett H.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Yang, Guang
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Xia, Shi Mao
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Montefiori, David Charles
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Parks, Robert J.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Lloyd, Krissey E.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Scearce, Richard M.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Soderberg, Kelly A.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Cohen, Myron S.
United States, Raleigh
The University of North Carolina System
Kamanga, Gift
Malawi, Lilongwe
Unc Project-malawi
Louder, Mark K.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Tran, Lillian
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Chen, Yue
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Cai, Fangping
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Chen, Sheri
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Moquin, Stephanie
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Du, Xiulian
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Joyce, Michael Gordon
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Srivatsan, Sanjay
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Zhang, Baoshan
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Zheng, Anqi
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Shaw, George M.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Hahn, Beatrice H.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Kepler, Thomas B.
United States, Boston
Boston University
Korber, Bette T.
United States, Los Alamos
Los Alamos National Laboratory Theoretical Division
Kwong, Peter D.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Mascola, John R.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Haynes, Barton F.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Becker, Jesse
United States, Bethesda
National Institutes of Health Nih
Benjamin, Betty
United States, Bethesda
National Institutes of Health Nih
Blakesley, Robert W.
United States, Bethesda
National Institutes of Health Nih
Bouffard, Gerard G.
United States, Bethesda
National Institutes of Health Nih
Brooks, Shelise
United States, Bethesda
National Institutes of Health Nih
Coleman, Holly
United States, Bethesda
National Institutes of Health Nih
Dekhtyar, Mila
United States, Bethesda
National Institutes of Health Nih
Gregory, Michael
United States, Bethesda
National Institutes of Health Nih
Guan, Xiaobin
United States, Bethesda
National Institutes of Health Nih
Gupta, Jyoti
United States, Bethesda
National Institutes of Health Nih
Han, Joel
United States, Bethesda
National Institutes of Health Nih
Hargrove, April
United States, Bethesda
National Institutes of Health Nih
Ho, Shi Ling
United States, Bethesda
National Institutes of Health Nih
Johnson, Taccara
United States, Bethesda
National Institutes of Health Nih
Legaspi, Richelle
United States, Bethesda
National Institutes of Health Nih
Lovett, Sean
United States, Bethesda
National Institutes of Health Nih
Maduro, Quino
United States, Bethesda
National Institutes of Health Nih
Masiello, Cathy
United States, Bethesda
National Institutes of Health Nih
Maskeri, Baishali
United States, Bethesda
National Institutes of Health Nih
McDowell, Jenny
United States, Bethesda
National Institutes of Health Nih
Montemayor, Casandra
United States, Bethesda
National Institutes of Health Nih
Mulliki, James
United States, Bethesda
National Institutes of Health Nih
Park, Morgan
United States, Bethesda
National Institutes of Health Nih
Riebow, Nancy
United States, Bethesda
National Institutes of Health Nih
Schandler, Karen
United States, Bethesda
National Institutes of Health Nih
Schmidt, Brian
United States, Bethesda
National Institutes of Health Nih
Sison, Christina
United States, Bethesda
National Institutes of Health Nih
Stantripop, Mal
United States, Bethesda
National Institutes of Health Nih
Thomas, James Conley
United States, Bethesda
National Institutes of Health Nih
Thomas, Pamela J.
United States, Bethesda
National Institutes of Health Nih
Vemulapalli, Meg
United States, Bethesda
National Institutes of Health Nih
Young, Alice C.
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 961
Authors: 76
Affiliations: 12
Identifiers
Doi:
10.1038/nature12053
ISSN:
00280836
e-ISSN:
14764687
Research Areas
Genetics And Genomics
Infectious Diseases