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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Gender-specific associations of short sleep duration with prevalent and incident hypertension: The whitehall II study
Hypertension, Volume 50, No. 4, Year 2007
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Description
Sleep deprivation (≤5 hour per night) was associated with a higher risk of hypertension in middle-aged American adults but not among older individuals. However, the outcome was based on self-reported diagnosis of incident hypertension, and no gender-specific analyses were included. We examined cross-sectional and prospective associations of sleep duration with prevalent and incident hypertension in a cohort of 10 308 British civil servants aged 35 to 55 years at baseline (phase 1: 1985-1988). Data were gathered from phase 5 (1997-1999) and phase 7 (2003-2004). Sleep duration and other covariates were assessed at phase 5. At both examinations, hypertension was defined as blood pressure ≥140/90 mm Hg or regular use of antihypertensive medications. In cross-sectional analyses at phase 5 (n=5766), short duration of sleep (≤5 hour per night) was associated with higher risk of hypertension compared with the group sleeping 7 hours, among women (odds ratio: 2.01; 95% CI: 1.13 to 3.58), independent of confounders, with an inverse linear trend across decreasing hours of sleep (P=0.003). No association was detected in men. In prospective analyses (mean follow-up: 5 years), the cumulative incidence of hypertension was 20.0% (n=740) among 3691 normotensive individuals at phase 5. In women, short duration of sleep was associated with a higher risk of hypertension in a reduced model (age and employment) (6 hours per night: odds ratio: 1.56 [95% CI: 1.07 to 2.27]; ≤5 hour per night: odds ratio: 1.94 [95% CI: 1.08 to 3.50] versus 7 hours). The associations were attenuated after accounting for cardiovascular risk factors and psychiatric comorbidities (odds ratio: 1.42 [95% CI: 0.94 to 2.16]; odds ratio: 1.31 [95% CI: 0.65 to 2.63], respectively). Sleep deprivation may produce detrimental cardiovascular effects among women. © 2007 American Heart Association, Inc.
Authors & Co-Authors
Cappuccio, Francesco Paolo
United Kingdom, Coventry
Warwick Medical School
United Kingdom, Coventry
University Hospitals Coventry and Warwickshire Nhs Trust
Stranges, S.
United Kingdom, Coventry
Warwick Medical School
Kandala, Ngianga Bakwin
United Kingdom, Coventry
Warwick Medical School
Taggart, Frances M.
United Kingdom, Coventry
Warwick Medical School
Kumari, Meena
United Kingdom, London
Ucl Medical School
Ferrie, Jane Elizabeth
United Kingdom, London
Ucl Medical School
Brunner, Eric John
United Kingdom, London
Ucl Medical School
Marmot, M. G.
United Kingdom, London
Ucl Medical School
Statistics
Citations: 459
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1161/HYPERTENSIONAHA.107.095471
ISSN:
0194911X
Research Areas
Mental Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Participants Gender
Male
Female