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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones
Bioorganic and Medicinal Chemistry Letters, Volume 21, No. 10, Year 2011
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Description
We report here the synthesis and in vitro antitubercular activity of a new series of ferrocenyl derivatives. The quinoline-ferrocene hybrid 5 exhibited significant activity (MIC = 2.5-5 μg/ml) against Mycobacterium tuberculosis. Results indicate that such hybrid compounds provide an efficient approach for future pharmacological developments to fight against tuberculosis. Moreover, the antimalarial drug candidate ferroquine (FQ, SSR97193) was also evaluated mainly because of its structural similarity. FQ was found to display moderate inhibitory activity (MIC = 10-15 μg/ml) against M. tuberculosis. This new drug may offer an interesting alternative in endemic area where malaria and tuberculosis coexist. © 2011 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Mahajan, Aman
South Africa, Cape Town
University of Cape Town
Kremer, Laurent Daniel
France, Montpellier
Laboratory of Pathogen Host Interactions
Louw, Stefan
South Africa, Cape Town
University of Cape Town
Guéradel, Yann
France, Lille
Université de Lille
France, Villeneuve-d'ascq
Unité de Glycobiologie Structurale et Fonctionnelle Ugsf
Chibale, Kelly
South Africa, Cape Town
University of Cape Town
Biot, Christophe
France, Lille
Université de Lille
France, Villeneuve-d'ascq
Unité de Glycobiologie Structurale et Fonctionnelle Ugsf
Statistics
Citations: 75
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.bmcl.2011.03.082
ISSN:
0960894X
Research Areas
Infectious Diseases