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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Microscopic-observation drug susceptibility assay provides rapid and reliable identification of MDR-TB
International Journal of Tuberculosis and Lung Disease, Volume 12, No. 3, Year 2008
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Description
BACKGROUND: Liquid culture systems are more rapid and sensitive for both the detection and drug susceptibility testing (DST) of Mycobacterium tuberculosis. SETTING: St Peter's TB Specialised Hospital and public health laboratory, Addis Ababa. OBJECTIVE: To compare the microscopic-observation drug susceptibility (MODS) assay with the BACTEC-MGIT 960 system for isoniazid and rifampicin DST (i.e., multidrug-resistant tuberculosis [MDR-TB] identification) of M. tuberculosis. DESIGN: The evaluation was based on 58 smear- and culture-positive sputum samples from patients diagnosed in Addis Ababa, Ethiopia. BACTEC-MGIT was used as the reference standard. RESULTS: For the detection of MDR-TB, MODS has a sensitivity, specificity and accuracy rate of respectively 95%, 100% and 98.3% (κ 0.981, concordance 98.3%). Concurrent culture detection and DST results are obtained in a median of 9 days with MODS, while indirect DST results with BACTEC-MGIT are obtained in a median of 8 days (this does not include time to primary isolate). CONCLUSION: MODS is an accurate, rapid and relatively inexpensive method for the identification of MDR-TB. © 2008 The Union.
Authors & Co-Authors
Ejigu, G. S.
Ethiopia, Awassa
Hawassa University
Ethiopia, Addis Ababa
School of Medicine
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Woldeamanuel, Yimtubezinash
Ethiopia, Addis Ababa
School of Medicine
Shah, N. Sarita
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Gebyehu, M.
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Selassie, Alemayehu
Ethiopia, Addis Ababa
St. Peter's tb Specialised Hospital
Lemma, Eshetu
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Shiferaw, Girum
Ethiopia, Awassa
Hawassa University
Statistics
Citations: 7
Authors: 7
Affiliations: 5
Identifiers
ISSN:
10273719
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Ethiopia