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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A dietary pattern protective against type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC) - Potsdam Study cohort
Diabetologia, Volume 48, No. 6, Year 2005
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Description
Aims/hypothesis: The aim of this study was to identify a dietary pattern associated with diabetes-related biomarkers and to investigate whether this pattern is associated with the incidence of type 2 diabetes. Methods: A nested case-control study of 192 cases of incident type 2 diabetes and 382 control subjects matched for sex and age was conducted. All subjects were participants in the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Dietary pattern score was derived using intake data on 48 food groups as exposure variables and the biomarkers HbA 1c, HDL cholesterol, C-reactive protein and adiponectin as response variables in reduced rank regression. The association of the score with diabetes risk was estimated by conditional logistic regression analysis. Results: A high score for the identified dietary pattern was characterised by a high intake of fresh fruit and a low intake of high-caloric soft drinks, beer, red meat, poultry, processed meat, legumes and bread (excluding wholegrain bread). Subjects with high scores had high plasma concentrations of HDL cholesterol and adiponectin and low plasma concentrations of HbA1c and C-reactive protein. After multivariate adjustment, the odds ratios for type 2 diabetes across increasing quintiles of the dietary pattern score were 1.0, 0.59, 0.51, 0.26 and 0.27, respectively (p=0.0006 for trend). Conclusions/interpretation: A high score for the identified dietary pattern is associated with a more favourable biomarker profile and a substantially reduced incidence of type 2 diabetes. © Springer-Verlag 2005.
Authors & Co-Authors
Heidemann, Christin
Germany, Nuthetal
German Institute of Human Nutrition
Hoffmann, Kurt
Germany, Nuthetal
German Institute of Human Nutrition
Spranger, Joachim Andreas
Germany, Nuthetal
German Institute of Human Nutrition
Germany, Berlin
Charité – Universitätsmedizin Berlin
Klipstein-Grobusch, Kerstin
Germany, Nuthetal
German Institute of Human Nutrition
Möhlig, Matthias
Germany, Nuthetal
German Institute of Human Nutrition
Germany, Berlin
Charité – Universitätsmedizin Berlin
Pfeiffer, Andreas F.H.
Germany, Nuthetal
German Institute of Human Nutrition
Germany, Berlin
Charité – Universitätsmedizin Berlin
Boeing, Heiner
Germany, Nuthetal
German Institute of Human Nutrition
Statistics
Citations: 182
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1007/s00125-005-1743-1
ISSN:
0012186X
Research Areas
Cancer
Food Security
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative