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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Acid-base status in paediatric plasmodium falciparum malaria
QJM, Volume 86, No. 2, Year 1993
Notification
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Description
We measured the acid-base status of children with falciparum malaria in order to determine the prognostic significance and rate of resolution of acidaemia in patients with severe disease. We prospectively studied 141 Malawian children who were admitted to Hospital, with falciparum malaria, 60 of whom had cerebral malaria (unrous-able coma, unable to localize a painful stimulus). Of the 60 patients with cerebral malaria 25 (42%) were acidaemic (capillary blood pH < 7.3); of 81 children with uncomplicated malaria 4 (5%) were acidaemic (p<0.0001). Eleven patients died; of these, eight presented with cerebral malaria, eight with acidaemia and seven with both. The strong association of altered acid-base status with disease severity and mortality was independent of other previously identified predictors of illness and death in malaria. Acidaemia was not associated with shock, bacteraemia or hypoxaemia. Acidaemic patients had a slower mean respiratory rate and a higher incidence of respiratory rhythm abnormalities than other patients, suggesting that acidaemia is in part the result of inadequate respiratory compensation for metabolic acidosis. Although acidaemia is quickly corrected by fluids and antimalarial drugs, specific therapy to correct acidaemia needs evaluation in children with severe malaria. © 1993 Oxford University Press.
Authors & Co-Authors
Molyneux, Malcolm Edward
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Taylor, Terrie E.
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
United States, East Lansing
Michigan State University
Borgstein, Arabella
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Statistics
Citations: 3
Authors: 3
Affiliations: 3
Identifiers
ISSN:
14602725
e-ISSN:
14602393
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study