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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Legume genome evolution viewed through the Medicago truncatula and Lotus japonicus genomes
Proceedings of the National Academy of Sciences of the United States of America, Volume 103, No. 40, Year 2006
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Description
Genome sequencing of the model legumes, Medicago truncatula and Lotus japonicus, provides an opportunity for large-scale sequence-based comparison of two genomes in the same plant family. Here we report synteny comparisons between these species, including details about chromosome relationships, large-scale synteny blocks, microsynteny within blocks, and genome regions lacking clear correspondence. The Lotus and Medicago genomes share a minimum of 10 large-scale synteny blocks, each with substantial collinearity and frequently extending the length of whole chromosome arms. The proportion of genes syntenic and collinear within each synteny block is relatively homogeneous. Medicago-Lotus comparisons also indicate similar and largely homogeneous gene densities, although gene-containing regions in Mt occupy 20-30% more space than Lj counterparts, primarily because of larger numbers of Mt retrotransposons. Because the interpretation of genome comparisons is complicated by large-scale genome duplications, we describe synteny, synonymous substitutions and phylogenetic analyses to identify and date a probable whole-genome duplication event. There is no direct evidence for any recent large-scale genome duplication in either Medicago or Lotus but instead a duplication predating speciation. Phylogenetic comparisons place this duplication within the Rosid I clade, clearly after the split between legumes and Salicaceae (poplar). © 2006 by The National Academy of Sciences of the USA.
Authors & Co-Authors
Cannon, Steven B.
United States, Minneapolis
University of Minnesota Twin Cities
United States, Ames
Iowa State University
Sterck, Lieven
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Rombauts, Stéphane
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Sato, Shusei
Japan, Kisarazu
Kazusa Dna Research Institute
Cheung, Foo K.
United States, Rockville
J. Craig Venter Institute
Gouzy, Jérõme
France, Paris
Cnrs Centre National de la Recherche Scientifique
Mudge, Joann
United States, Minneapolis
University of Minnesota Twin Cities
Spannagl, Manuel
Unknown Affiliation
Monaghan, Erin L.
United States, Rockville
J. Craig Venter Institute
Nicholson, Christine
United Kingdom, Hinxton
Wellcome Sanger Institute
Humphray, Sean J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Schoof, Heiko
Germany, Koln
Max Planck Institute for Plant Breeding Research
Mayer, Klaus F.X.
Unknown Affiliation
Rogers, Jane
United Kingdom, Hinxton
Wellcome Sanger Institute
Quétier, Francis
France, Evry
Genoscope - Centre National de Séquençage
Oldroyd, Giles E.D.
United Kingdom, Norwich
John Innes Centre
Debéllé, Frédéric
France, Paris
Cnrs Centre National de la Recherche Scientifique
Cook, Douglas R.
United States, Davis
University of California, Davis
Retzel, Ernest F.
Unknown Affiliation
Town, Christopher D.
United States, Rockville
J. Craig Venter Institute
Tabata, Satoshi
Japan, Kisarazu
Kazusa Dna Research Institute
Van de Peer, Y.
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Young, Nevin Dale
United States, Minneapolis
University of Minnesota Twin Cities
Statistics
Citations: 301
Authors: 23
Affiliations: 13
Identifiers
Doi:
10.1073/pnas.0603228103
ISSN:
00278424
Research Areas
Genetics And Genomics