Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Prevalence of human papillomavirus genotypes and associated cervical squamous intraepithelial lesions in HIV-infected women in Botswana
Journal of Medical Virology, Volume 83, No. 10, Year 2011
Notification
URL copied to clipboard!
Description
Human papillomaviruses (HPV) constitute one of the most prevalent sexually transmitted infections and are the etiological agents for invasive cervical cancer, the predominant cancer among women in Botswana. However, the prevalence of HPV genotypes in Botswana has yet to be reported. One hundred thirty-nine endocervical swabs were taken at baseline from HIV-1 infected, HSV-2 seropositive women enrolled in a longitudinal cohort study designed to assess the influence of herpes simplex virus-2 (HSV-2) infection on genital tract shedding of HIV-1. Extracted DNA was evaluated for the presence of low-risk and high-risk HPV using the Roche Linear Array. Genotyping identified HPV in 95 of 139 women of which 61/95 were infected with high-risk HPV and 56/95 with low-risk HPV. The median number of genotypes was 2 (IQR: 1-4). The most prevalent HPV genotype in HIV-infected women was HPV 58. Abnormal cervical cytology was detected in 87/127 women and was associated with contemporaneous HPV infection (RR=1.43, 95% CI: 1.05-1.93; P=0.02). HPV prevalence was high among HIV-infected women with infection by multiple genotypes being widespread. The associations attributed to specific oncogenic HPV subtypes and cervical squamous intraepithelial lesions presented here provide critical information to inform future vaccine policy within Botswana. © 2011 Wiley-Liss, Inc..
Authors & Co-Authors
MacLeod, Iain J.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
O'Donnell, Belinda
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Moyo, Sikhulile M.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Lockman, Shahin
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Brigham and Women's Hospital
Shapiro, Roger L.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Beth Israel Deaconess Medical Center
Kayembe, Mukendi K.A.
Botswana, Gaborone
National Health Laboratory
van Widenfelt, Erik
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Makhema, Joseph M.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Essex, Max E.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Wester, Carolyn William
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Statistics
Citations: 33
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1002/jmv.22178
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Botswana
Participants Gender
Female