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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria
PLoS Medicine, Volume 6, No. 4, Article e1000055, Year 2009
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Description
Background: Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted. To that end we have characterised the evolutionary origins of antifolate resistance mutations in the dihydropteroate synthase (dhps) gene and mapped their contemporary distribution. Methods and Findings: We used microsatellite polymorphism flanking the dhps gene to determine which resistance alleles shared common ancestry and found five major lineages each of which had a unique geographical distribution. The extent to which allelic lineages were shared among 20 African Plasmodium falciparum populations revealed five major geographical groupings. Resistance lineages were common to all sites within these regions. The most marked differentiation was between east and west African P. falciparum, in which resistance alleles were not only of different ancestry but also carried different resistance mutations. Conclusions: Resistant dhps has emerged independently in multiple sites in Africa during the past 10-20 years. Our data show the molecular basis of resistance differs between east and west Africa, which is likely to translate into differing antifolate sensitivity. We have also demonstrated that the dispersal patterns of resistance lineages give unique insights into recent parasite migration patterns. © 2009 Pearce et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2661256/bin/pmed.1000055.s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2661256/bin/pmed.1000055.s002.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2661256/bin/pmed.1000055.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2661256/bin/pmed.1000055.s004.doc
Authors & Co-Authors
Pearce, Richard J.
Unknown Affiliation
Pota, Hirva
Unknown Affiliation
Evehe, Marie Solange Bebandue
Unknown Affiliation
Bâ, Elhadji Hadj
Unknown Affiliation
Mombo-Ngoma, Ghyslain
Unknown Affiliation
Malisa, Allen Lewis
Unknown Affiliation
Ord, Rosalynn Louise
Unknown Affiliation
Inojosa, Walter O.
Unknown Affiliation
Matondo, Alexandre
Unknown Affiliation
Diallo, Diadier Diadier
Unknown Affiliation
Mbacham, Wilfred Fon
Unknown Affiliation
van den Broek, I. V.
Unknown Affiliation
Swarthout, Todd D.
Unknown Affiliation
Getachew, Asefaw
Unknown Affiliation
Dejene, Seyoum
Unknown Affiliation
Grobusch, Martín Peter
Unknown Affiliation
Njie, Fanta
Unknown Affiliation
Dunyo, Samuel K.
Unknown Affiliation
Kweku, Margaret A.
Unknown Affiliation
Owusu-Agyei, Seth
Unknown Affiliation
Chandramohan, Daniel
Unknown Affiliation
Bonnet, Maryline M.B.
Unknown Affiliation
Guthmann, Jean Paul
Unknown Affiliation
Clarke, Siaân E.
Unknown Affiliation
Barnes, Karen Irma
Unknown Affiliation
Streat, Elizabeth
Unknown Affiliation
Katokele, Stark T.
Unknown Affiliation
Uusiku, Petrina
Unknown Affiliation
Agboghoroma, Chris O.
Unknown Affiliation
Elegba, O. Y.
Unknown Affiliation
Cissé, Badara
Unknown Affiliation
A-Elbasit, Ishraga E.
Unknown Affiliation
Giha, Hayder Ahmed
Unknown Affiliation
Kachur, Stephen Patrick
Unknown Affiliation
Lynch, Caroline A.
Unknown Affiliation
Rwakimari, John Bosco
Unknown Affiliation
Chanda-Kapata, Pascalina
Unknown Affiliation
Moonga, Hawela B.
Unknown Affiliation
Sharp, Brian L.
Unknown Affiliation
Naidoo, Inbarani
Unknown Affiliation
Roper, Cally
Unknown Affiliation
Statistics
Citations: 182
Authors: 41
Affiliations: 29
Identifiers
Doi:
10.1371/journal.pmed.1000055
ISSN:
15491277
e-ISSN:
15491676
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries