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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Niacin skin sensitivity is increased in adolescents at ultra-high risk for psychosis
PLoS ONE, Volume 11, No. 2, Article e0148429, Year 2016
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Description
Background: Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders. Methods: We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year transition outcome (UHR-T n = 11; UHR-NT n = 55) with healthy controls (HC n = 25) and first episode schizophrenia patients (FEP n = 25) treated with atypical antipsychotics. Results: Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups. As expected, niacin sensitivity of FEP was attenuated compared to HC group. In UHR individuals niacin sensitivity was inversely correlated with omega-6 and -9 fatty acids (FA), but positively correlated with phospholipase A2 (in7PLA2) activity, a marker of membrane lipid repair/remodelling. Conclusions: Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level. Our findings suggest that the emergence of psychosis is associated with an increased mobilisation of eicosanoids prior to the transition to psychosis possibly reflecting a "pro-inflammatory state", whereas thereafter eicosanoid mobilisation seems to be attenuated. Potential treatment implications for the UHR state should be further investigated. © 2016 Berger et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Authors & Co-Authors
Berger, Gregor E.
Switzerland, Zurich
Universität Zürich
Australia, Melbourne
Orygen Youth Health
Hipler, Uta Christina
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
Klier, Claudia M.
Austria, Vienna
Medizinische Universität Wien
Schloegelhofer, Monika
Austria, Vienna
Medizinische Universität Wien
Berk, Michael
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
McGorry, Patrick D.
Australia, Melbourne
Orygen Youth Health
Amminger, G. Paul
Australia, Melbourne
Orygen Youth Health
Austria, Vienna
Medizinische Universität Wien
Statistics
Citations: 27
Authors: 7
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0148429
ISSN:
19326203
Research Areas
Health System And Policy
Mental Health