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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells
Science Advances, Volume 9, No. 44, Article eadh2284, Year 2023
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Description
Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) hospitalized with SAM in Zambia and Zimbabwe (n = 141) have distinct capacity to respond to bacteria relative to adequately nourished healthy controls (n = 92). SAM inpatients had higher neutrophil and monocyte Escherichia coli binding capacity but lower monocyte activation and proinflammatory mediator secretion in response to lipopolysaccharide or heat-killed Salmonella typhimurium than controls. Among SAM cases, wasting severity was negatively associated with cytokine secretion, children with HIV had lower monocyte activation, and the youngest children released the least myeloperoxidase upon stimulation. Inpatient bacterial binding capacity and monocyte activation were associated with higher odds of persistent SAM at discharge, a risk factor for subsequent mortality. Thus, SAM shifts innate immune cell function, favoring bacterial containment over proinflammatory activation, which may contribute to health deficits after discharge. Copyright © 2023 The Authors, some rights reserved.
Authors & Co-Authors
Mutasa, Kuda E.
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Rukobo, Sandra D.
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Govha, Margaret
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Mushayanembwa, Patience
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Mwakamui, Simutanyi
Zambia, Lusaka
University of Zambia School of Medicine
Zyambo, Kanekwa
Zambia, Lusaka
University of Zambia School of Medicine
Dumbura, Cherlynn
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Tome, Joice
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Runodamoto, Thompson
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Chidamba, Leah
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Majo, Florence D.
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Ngosa, Deophine
Zambia, Lusaka
University of Zambia School of Medicine
Chandwe, Kanta
Zambia, Lusaka
University of Zambia School of Medicine
Kapoma, Chanda
Zambia, Lusaka
University of Zambia School of Medicine
Mwapenya, Benjamin
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Mufukari, Wadzanai
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Sturgeon, Jonathan Peter
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
United Kingdom, London
Queen Mary University of London
Robertson, Ruairi C.
United Kingdom, London
Queen Mary University of London
Smuk, Melanie
United Kingdom, London
Queen Mary University of London
Ntozini, Robert
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Nathoo, Kusum Jackison
Zimbabwe, Harare
University of Zimbabwe
Amadi, Beatrice C.
Zambia, Lusaka
University of Zambia School of Medicine
Kelly, Paul M.
Zambia, Lusaka
University of Zambia School of Medicine
United Kingdom, London
Queen Mary University of London
Bwakura-Dangarembizi, Mutsa F.
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
Zimbabwe, Harare
University of Zimbabwe
Prendergast, Andrew J.
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
United Kingdom, London
Queen Mary University of London
Bourke, Claire D.
Zimbabwe, Harare
Zvitambo Institute for Maternal and Child Health Research
United Kingdom, London
Queen Mary University of London
Statistics
Authors: 26
Affiliations: 4
Identifiers
Doi:
10.1126/SCIADV.ADH2284
ISSN:
23752548
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Locations
Zambia
Zimbabwe