Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First multicenter study for risk factors for hepatocellular carcinoma development in North Africa
World Journal of Hepatology, Volume 3, No. 1, Year 2011
Notification
URL copied to clipboard!
Description
Aim: To assess the role of the major risk factors for hepatocellular carcinoma (HCC) development in the western part of North Africa. Methods: A multicenter case control study was conducted in Tunisia, Morocco and Algeria in collaboration with Pasteur Institutes in these countries. A total of 164 patients with HCC and 250 control subjects without hepatic diseases were included. Prevalences of HBsAg, anti-hepatitis C virus (HCV) and diabetes were assessed. HCV and HBV genotyping were performed for anti-HCV and HBsAg positive patients. Results: The mean age of patients was 62 ± 10 years old for a 1.5 M:F sex ratio. Sixty percent of HCC patients were positive for anti-HCV and 17.9% for HBsAg. Diabetes was detected in 18% of cases. Odd ratio (OR) and 95% confidence intervals (CI) were 32.0 (15.8 - 65.0), 7.2 (3.2 - 16.1) and 8.0 (3.1 - 20.0) for anti-HCV, HBsAg and diabetes respectively. Multivariate analysis indicated that the three studied factors were independent. 1b HCV genotype and D HBV genotype were predominant in HCC patients. HCV was the only risk factor significantly associated with an excess of cirrhosis (90% vs 68% for all other risk factors collectively, P = 0.00168). Excessive alcohol consumption was reliably established for 19 (17.6%) cases among the 108 HCC patients for whom data is available. Conclusion: HCV and HBV infections and diabetes are the main determinants of HCC development in North Africa. An active surveillance and secondary prevention programs for patients with chronic hepatitis and nutrition- associated metabolic liver diseases are the most important steps to reduce the risk of HCC in the region. © 2011 Baishideng.
Authors & Co-Authors
Bahri, Olfa
Tunisia, Tunis
Institut Pasteur de Tunis
Ezzikouri, Sayeh
Morocco, Casablanca
Institut Pasteur du Maroc
Alaya-Bouafif, Ben
Tunisia, Tunis
Institut Pasteur de Tunis
Iguer, F.
Algeria, Algiers
Institut Pasteur - Alger
Essaïd, Abdellah Elfeydi
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Mestiri, Hafedh
Tunisia, La Marsa
Université de Tunis el Manar, Hôpital Mongi Slim
Benazzouz, Moustapha
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Khalfallah, Taher
Tunisia, La Marsa
Université de Tunis el Manar, Hôpital Mongi Slim
Afifi, Rajae
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Elkihal, Latifa
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Berkane, S.
Algeria, Oran
Centre Hospitalier - Universitaire D'oran
Marchio, Agnès
France, Paris
Inserm
Debzi, Nabil
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Dejean, Anne
France, Paris
Inserm
Pineau, Pascal
France, Paris
Inserm
Triki, Henda
Tunisia, Tunis
Institut Pasteur de Tunis
Benjelloun, Soumaya
Morocco, Casablanca
Institut Pasteur du Maroc
Statistics
Citations: 40
Authors: 17
Affiliations: 8
Identifiers
Doi:
10.4254/wjh.v3.i1.24
e-ISSN:
19485182
Research Areas
Cancer
Food Security
Genetics And Genomics
Infectious Diseases
Noncommunicable Diseases
Substance Abuse
Study Design
Case-Control Study
Study Locations
Multi-countries
Algeria
Morocco
Tunisia