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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Molecular interaction of Acetylcholinesterase with Carnosic acid derivatives: A neuroinformatics study
CNS and Neurological Disorders - Drug Targets, Volume 13, No. 3, Year 2014
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Description
Alzheimer's disease is a progressive degenerative disease of the brain marked by gradual and irreversible declines in cognitive functions. Acetylcholinesterase (AChE) plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of its substrate, "acetylcholine". The deficit level of acetylcholine leads to deprived nerve impulse transmission. Thus the cholinesterase inhibitors would reverse the deficit in acetylcholine level and consequently may reverse the memory impairments, which is characteristic of the Alzheimer's disease. The molecular interactions between AChE and Carnosic acid, a well known antioxidant substance found in the leaves of the rosemary plant has always been an area of interest. Here in this study we have performed in silico approach to identify carnosic acid derivatives having the potential of being a possible drug candidate against AChE. The best candidates were selected on the basis of the results of different scoring functions. © 2014 Bentham Science Publishers.
Authors & Co-Authors
Merad, Meriem
Algeria, Tlemcen
Université Abou Bekr Belkaid Tlemcen
Soufi, W.
Algeria, Tlemcen
Université Abou Bekr Belkaid Tlemcen
Ghalem, Saïd
Algeria, Tlemcen
Université Abou Bekr Belkaid Tlemcen
Boukli, F.
Algeria, Tlemcen
Université Abou Bekr Belkaid Tlemcen
Baig, Mohammad Hassan
India, Lucknow
Integral University
Ahmad, Khurshid
India, Lucknow
Integral University
Kamal, Mohammad Amjad
Saudi Arabia, Jeddah
King Abdulaziz University
Statistics
Citations: 21
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.2174/18715273113126660157
ISSN:
18715273
e-ISSN:
19963181