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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer
Cancer Genetics and Cytogenetics, Volume 145, No. 2, Year 2003
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Description
Microsomal epoxide hydrolase (mEH) gene is polymorphic and its enzyme is involved in the activation and subsequent detoxification of several tobacco carcinogens, for example polycyclic aromatic hydrocarbons. Therefore, we have investigated the association of two polymorphisms at exons 3 and 4 of the mEH gene with the development of lung cancer in 110 patients and 119 matched controls. In addition, we have investigated the relationship between the different mEH alleles and the frequency of chromosome aberrations (CA), as an approach to understand the role of genetic susceptibility on cancer risk. Our results show that only the homozygous exon 4 fast genotype is significantly associated with increased risk for lung cancer (odds ratio [OR] = 6.26; 95% confidence interval [CI] = 1.02-38.3). When the exons 3 and 4 polymorphisms are considered together, patients carrying the high enzyme activity genotype have a significantly increased risk for lung cancer (OR = 2.46; 95% CI = 1.06-5.68). More importantly, the increased risk for this group is confirmed by their having the highest frequency of CA compared to any other genotype groups. In addition, genotypes with higher risk had consistently more CA than those with lower risk. Our CA data also indicates that the low activity genotype may exert a protective role in cigarette smokers, as it was associated with a significant decrease in CA compared to the high and intermediate activity genotypes. In conclusion, the CA data provides evidence to support that susceptibility mEH alleles are significantly involved with the development of lung cancer from cigarette smoking. © 2003 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Cajas-Salazar, N.
United States, Galveston
The University of Texas Medical Branch at Galveston
Colombia, Popayan
Universidad Del Cauca
Au, William W.
United States, Galveston
The University of Texas Medical Branch at Galveston
Zwischenberger, Joseph B.
United States, Galveston
University of Texas Medical Branch, School of Medicine
Sierra-Tórres, Carlos Hernán
United States, Galveston
The University of Texas Medical Branch at Galveston
Colombia, Popayan
Universidad Del Cauca
Salama, Salama Abdou
United States, Galveston
The University of Texas Medical Branch at Galveston
Egypt, Cairo
Faculty of Pharmacy
Alpard, Scott K.
United States, Galveston
University of Texas Medical Branch, School of Medicine
Tyring, Stephen Keith
United States, Galveston
The University of Texas Medical Branch at Galveston
Statistics
Citations: 43
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/S0165-4608(03)00058-X
ISSN:
01654608
Research Areas
Cancer
Genetics And Genomics
Substance Abuse
Study Design
Case-Control Study