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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Expansion of European vacA and cagA alleles to East-Asian Helicobacter pylori strains in Cambodia
Infection, Genetics and Evolution, Volume 11, No. 8, Year 2011
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Description
Helicobacter pylori infection is associated with gastric cancer (GC). The highest incidence rates have been described in Asia, but regional variations exist that do not match the distribution of infection prevalence rates. The aim of the study was to examine the possible contribution of H. pylori virulence factors to geographic differences in the incidence of GC across East and Southeast Asia. We studied 66 isolates from Cambodian patients that had previously been assigned to two genetic populations based on sequences of seven housekeeping genes, namely hpEurope (n=34, 51.5%) and hpEastAsia, subpopulation hspEAsia (n=32, 48.5%). These strains were characterized with respect to vacA polymorphism and cagA status by PCR, and the CagA C-terminal region was sequenced. We also sequenced the complete cagA gene from 10 hpEurope and 10 hspEAsia strains chosen at random. The cagA gene was present in 92.4% of the 66 isolates and was mainly of Western type (n=36, 59.0%). hspEAsia strains carrying East-Asian CagA and the m1-type vacA allele (15.2%) were less frequent among the 66 Cambodian isolates than reported in East Asian countries, a finding that might partly explain the intermediate incidence of GC in Cambodia, and by extension, in Southeast Asia (except for Vietnam). The observed high prevalence of s1a alleles (34.4%) and Western CagA (28.1%) among hspEAsia strains indicates frequent introgression of European vacA and cagA alleles into East Asian H. pylori strains. This expansion might have severe consequences for individual disease outcome. © 2011 Elsevier B.V.
Authors & Co-Authors
Breurec, Sébastien
Senegal, Dakar
Institut Pasteur de Dakar
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Guillard, Bertrand
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Hem, Sopheak
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Papadakos, Konstantinos S.
Greece, Athens
Hellenic Pasteur Institute
Brisse, Sylvain
France, Paris
Institut Pasteur, Paris
Huerre, Michel René
France, Paris
Institut Pasteur, Paris
Monchy, Didier
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
France, Paris
Institut Pasteur, Paris
Oung, Chakravuth
Cambodia, Phnom Penh
Calmette Hospital
Sgouras, Dionyssios N.
Greece, Athens
Hellenic Pasteur Institute
Tan, Tek Sreng
Cambodia, Phnom Penh
Private Medical Center
Thiberge, Jean Michel
France, Paris
Institut Pasteur, Paris
Vong, Sirenda
Cambodia, Phnom Penh
Pasteur Institute
Raymond, Josette
France, Paris
Institut Pasteur, Paris
Linz, Bodo
United States, University Park
Pennsylvania State University
Statistics
Citations: 14
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1016/j.meegid.2011.08.007
ISSN:
15671348
e-ISSN:
15677257
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study