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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Association between lifetime cigarette smoking and Lewy body accumulation
Brain Pathology, Volume 20, No. 2, Year 2010
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Description
Cigarette smoking has been associated repeatedly in observational studies with decreased risk of Parkinson's disease (PD), but its relationship to the risk of dementia or Alzheimer's disease (AD) is inconsistent. All of these studies have used clinical diagnoses of disease. We tested the hypothesis that lifetime cigarette use might be associated with reduced risk of neuropathologic changes of Lewy-related pathology (LRP) in multiple brain regions or with reduced risk of consensus neuropathologic changes of AD in a prospective community-based study of brain aging and dementia, the Adult Changes in Thought (ACT) study. We observed that heavy lifetime cigarette smoking (>50 pack years) was associated with significantly reduced relative risk (RR) for LRP, but not AD-type pathologic changes, after correcting for selection bias, and with significantly reduced frequency of LRP in the substantia nigra. These findings are the first of which we are aware to associate reduced LRP in human brain with any exposure, and substantiate observational studies that have associated cigarette smoking with reduced risk of PD. Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means. © 2009 International Society of Neuropathology.
Authors & Co-Authors
Tsuang, Debby W.
United States, Seattle
University of Washington
United States, Seattle
Va Puget Sound Health Care System
Larson, Eric B.
United States, Seattle
University of Washington
United States, Seattle
Group Health Center for Health Studies
Shofer, Jane B.
United States, Seattle
University of Washington
Thompson, Mary Lou
United States, Seattle
University of Washington
Crane, Paul K.
United States, Seattle
University of Washington
Statistics
Citations: 31
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1111/j.1750-3639.2009.00296.x
ISSN:
17503639
Research Areas
Environmental
Mental Health
Substance Abuse
Study Design
Cohort Study