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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Does the sex of acute stroke patients influence the effectiveness of rt-PA?
BMC Neurology, Volume 14, No. 1, Article 60, Year 2014
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Description
Background: Women have been reported to show more frequent recanalization and better recovery after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) treatment for acute stroke compared with men. To investigate this we studied a series of stroke patients receiving IV rt-PA and undergoing acute transcranial doppler (TCD) examination.Methods: Acute stroke patients received IV rt-PA and had acute TCD examination within 4 hours of symptom onset at 4 major stroke centers. TCD findings were interpreted using the Thrombolysis in Brain Ischemia (TIBI) flow grading system. The recanalization rates, and poor 3-month outcomes (modified Rankin scale >2) of men and women were compared using the chi-square test. Multiple regression analysis was used to assess sex as a predictor of recanalization and poor 3-month outcome after controlling for age, baseline NIH Stroke Scale (NIHSS), time to treatment, hypertension, and blood glucose.Results: 369 patients had TCD examinations before or during IV rt-PA treatment. The 199 (53.9%) men and 170 (46.1%) women had mean ages of 67 ± 13 and 70 ± 14 years, respectively. The sexes did not differ significantly in baseline stroke severity, time to TCD examination, or time to thrombolysis. Of the men, 68 (34.2%) had complete recanalization, 58 (29.1%) had partial recanalization, and 73 (36.6%) had no recanalization. Of the women, 53 (31.2%) had complete recanalization, 46 (27%) had partial recanalization, and 71 (41.8%) had no recanalization (p = 0.6). Multiple regression analyses showed no difference between the sexes in recanalization rate, time to recanalization, or clinical outcome at 3 months.Conclusions: In our study; sex is not a significant predictor of recanalization rate, time to recanalization or 3-month outcome in stroke patients following IV rt-PA.Trial registration: Data from CLOTBUST trial Clinicaltrails.gov Identifier: NCT01240356. © 2014 Al-hussain et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Al-Hussain, Fawaz Abdulaziz
Saudi Arabia, Riyadh
King Saud University
Hussain, Shazam Shazam
United States, Cleveland
Cleveland Clinic Foundation
Molina, Carlos Alberto
Spain, Barcelona
Hospital Universitari Vall D'hebron
Uchino, Ken
United States, Cleveland
Cleveland Clinic Foundation
Shuaib, Ashfaq
Canada, Edmonton
University of Alberta
Demchuk, Andrew M.
Canada, Calgary
University of Calgary
Alexandrov, Andrei V.
United States, Birmingham
The University of Alabama at Birmingham
Saqqur, Maher
Canada, Edmonton
University of Alberta
Statistics
Citations: 10
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2377-14-60
e-ISSN:
14712377
Research Areas
Noncommunicable Diseases
Study Approach
Quantitative
Participants Gender
Male
Female