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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Unveiling P. vivax invasion pathways in Duffy-negative individuals
Cell Host and Microbe, Volume 31, No. 12, Year 2023
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Description
Vivax malaria has long been thought to be absent from sub-Saharan Africa owing to the high proportion of individuals lacking the Duffy antigen receptor for chemokines (DARC) in their erythrocytes. The interaction between P. vivax Duffy-binding protein (PvDBP) and DARC is assumed to be the main pathway used by merozoites to invade reticulocytes. However, the increasing number of reports of vivax malaria cases in genotypically Duffy-negative (DN) individuals has raised questions regarding the P. vivax invasion pathway(s). Here, we show that a subset of DN erythroblasts transiently express DARC during terminal erythroid differentiation and that P. vivax merozoites, irrespective of their origin, can invade DARC+ DN erythroblasts. These findings reveal that a large number of DN individuals may represent a silent reservoir of deep P. vivax infections at the sites of active erythropoiesis with low or no parasitemia, and it may represent an underestimated biological problem with potential clinical consequences in sub-Saharan Africa. © 2023 The Author(s)
Authors & Co-Authors
Bouyssou, Isabelle
France, Paris
Institut Pasteur, Paris
France, Paris
Sorbonne Université
Doderer-Lang, Cécile
France, Strasbourg
Université de Strasbourg
Schoenhals, Matthieu
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Rasoloharimanana, Lova Tsikiniaina
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Vigan-Womas, Inès
Senegal, Dakar
Institut Pasteur de Dakar
Ratsimbasoa, Arsène C.
Madagascar, Fianarantsoa
Université de Fianarantsoa
Abate, Andargie
Ethiopia, Addis Ababa
Addis Ababa University
Golassa, Lemu
Ethiopia, Addis Ababa
Addis Ababa University
Mabilotte, Solenne
France, Strasbourg
Université de Strasbourg
Guillotte-Blisnick, Micheline
France, Paris
Institut Pasteur, Paris
Chitnis, Chetan E.
France, Paris
Institut Pasteur, Paris
Strouboulis, John
United Kingdom, London
King's College London
Menard, Didier
France, Paris
Institut Pasteur, Paris
France, Strasbourg
Université de Strasbourg
France, Strasbourg
Les Hôpitaux Universitaires de Strasbourg
Statistics
Citations: 4
Authors: 13
Affiliations: 9
Identifiers
Doi:
10.1016/j.chom.2023.11.007
ISSN:
19313128
Research Areas
Infectious Diseases