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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cerebral biomarkers in women with preeclampsia are still elevated 1 year postpartum
American Journal of Hypertension, Volume 29, No. 12, Year 2016
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Description
BACKGROUND There is evidence of cerebral involvement among women with preeclampsia. Levels of the cerebral biomarkers neuron-specific enolase (NSE) and S100B are elevated during pregnancy in women developing preeclampsia. It is although not known if these biomarkers return to normal range postpartum. The aim with this study was to compare levels of S100B and NSE during pregnancy and 1 year postpartum in women who have had preeclampsia to women with normal pregnancies. METHODS This study was a longitudinal study of cases (n = 53) with preeclampsia and controls (n = 58) consisted of normal pregnant women in matched gestational weeks. Plasma samples were collected at inclusion during pregnancy and 1 year postpartum. Plasma samples were analyzed for levels of S100B and NSE by enzyme-linked immunosorbent assays kits. RESULTS Levels of NSE and S100B in women with preeclampsia were higher during pregnancy than in women with normal pregnancies. One year postpartum, women who have had preeclampsia still had a higher median level of both NSE (5.07 vs. 4.28 μg/l, P < 0.05) and S100B (0.07 vs. 0.06 μg/l, P < 0.05) compared to women with previous normal pregnancies. High levels of NSE and S100B postpartum remained associated with previous preeclampsia after adjustment for confounding factors. Levels of NSE correlated to S100B during pregnancy and postpartum. CONCLUSIONS Levels of NSE and S100B are still elevated 1 year postpartum in women who have had preeclampsia in contrast to women with previous normal pregnancies. We hypothesize that there might be a persistent cerebral involvement among women with preeclampsia even 1 year postpartum. © 2016 American Journal of Hypertension, Ltd. All rights reserved.
Authors & Co-Authors
Bergman, Lina
Sweden, Uppsala
Uppsala Universitet
Sweden, Falun
Center for Clinical Research
Åkerud, Helena
Sweden, Uppsala
Uppsala Universitet
Wikstrom̈, Anna Karin
Sweden, Uppsala
Uppsala Universitet
Sweden, Stockholm
Karolinska Institutet
Larsson, Margareta
Sweden, Uppsala
Uppsala Universitet
Statistics
Citations: 17
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1093/ajh/hpw097
ISSN:
08957061
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female