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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants
American Journal of Tropical Medicine and Hygiene, Volume 88, No. 2, Year 2013
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Description
Enteric infections are associated with linear growth failure in children. To quantify the association between intestinal inflammation and linear growth failure three commercially available enzyme-linked immunosorbent assays (neopterin [NEO], alpha-anti-trypsin [AAT], and myeloperoxidase [MPO]) were performed in a structured sampling of asymptomatic stool from children under longitudinal surveillance for diarrheal illness in eight countries. Samples from 537 children contributed 1,169 AAT, 916 MPO, and 954 NEO test results that were significantly associated with linear growth. When combined to form a disease activity score, children with the highest score grew 1.08 cm less than children with the lowest score over the 6-month period following the tests after controlling for the incidence of diarrheal disease. This set of affordable non-invasive tests delineates those at risk of linear growth failure and may be used for the improved assessments of interventions to optimize growth during a critical period of early childhood. Copyright © 2013 by The American Society of Tropical Medicine and Hygiene.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3583335/bin/SD2.pdf
Authors & Co-Authors
Kosek, Margaret N.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Haque, Rashidul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Moreira Lima, Aldo Ângelo
Brazil, Fortaleza
Universidade Federal do Ceará
Babji, Sudhir
India, Vellore
Christian Medical College, Vellore
Shrestha, Sanjaya Kumar
Nepal, Kathmandu
Walter Reed/afrims Research Unit Nepal Warun
Qureshi, Shahida Mumtaz
Pakistan, Karachi
The Aga Khan University
Amidou, Samie
South Africa, Thohoyandou
University of Venda
Mduma, Estomih R.
Tanzania, Mbulu
Haydom Lutheran Hospital
Lee, Gwenyth O.Neill
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Peñataro Yori, Pablo
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Guerrant, Richard Littleton
United States, Charlottesville
University of Virginia
Bhutta, Zulfiqar A.
Pakistan, Karachi
The Aga Khan University
Mason, Carl Jeffries
Thailand, Bangkok
Armed Forces Research Institute of Medical Sciences, Thailand
Kang, Gagandeep
India, Vellore
Christian Medical College, Vellore
Kabir, Mamun Shahidul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Amour, Caroline
Tanzania, Mbulu
Haydom Lutheran Hospital
Bessong, Pascal Obong
South Africa, Thohoyandou
University of Venda
Turab, Ali
Pakistan, Karachi
The Aga Khan University
Seidman, Jessica C.
United States, Bethesda
National Institutes of Health Nih
Paredes Olórtegui, Maribel
Peru, Lima
Asociacion Benefica Prisma Lima
Quetz, Josiane S.
Brazil, Fortaleza
Universidade Federal do Ceará
Lang, Dennis R.
United States, Bethesda
National Institutes of Health Nih
Gratz, Jean C.
United States, Charlottesville
University of Virginia
Miller, Mark A.
United States, Bethesda
National Institutes of Health Nih
Gottlieb, Michael
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 283
Authors: 25
Affiliations: 12
Identifiers
Doi:
10.4269/ajtmh.2012.12-0549
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study