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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The induction and persistence of T cell IFN-γ responses after vaccination or natural exposure is suppressed by Plasmodium falciparum
Journal of Immunology, Volume 179, No. 6, Year 2007
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Description
Epidemiological observations suggest that T cell immunity may be suppressed in malaria-endemic areas. In vitro studies, animal models, and limited data in humans link immunosuppression with malaria, malnutrition, and other parasitic infections. However, there are no data to determine whether malaria-induced immunosuppression is significant in the long-term, or relative data comparing it with other factors in malaria-endemic areas, so as to measure the impact of malaria, other parasitic disease, nutritional status, age. and location on the acquisition and longevity of IFN-γ responses in children in Kenya. We studied these factors in two cohorts of 1- to 6-year-old children in a malaria-endemic area. T cell responses were induced by vaccination in one cohort, and acquired as a result of natural exposure in a second cohort. Serial ELISPOT assays conducted over a 1-year period measured the induction and kinetics of IFN-γ production in response to the malaria Ag thrombospondin-related adhesion protein. Induced responses in both cohorts and the longevity of response in the vaccinated cohort were fitted to potential explanatory variables. Parasitemia was prospectively associated with reduced IFN-γ-producing T cells in both cohorts (by 15-25%), and both parasitemia and episodes of febrile malaria were associated with 19 and 31% greater attrition of T cell responses, respectively. Malaria may reduce the efficacy vaccinations such as bacillus Calmette-Guérin and investigational T cell-inducing vaccines, and may delay the acquisition of immunity following natural exposure to malaria and other pathogens. Copyright © 2007 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Bejon, Philip A.
Kenya, Nairobi
Kenya Medical Research Institute
Mwacharo, Jedidah K.
Kenya, Nairobi
Kenya Medical Research Institute
Kai, Oscar K.
Kenya, Nairobi
Kenya Medical Research Institute
Todryk, Stephen M.
United Kingdom, Oxford
University of Oxford
Keating, Sheila Marie
United Kingdom, Oxford
University of Oxford
Lowe, Brett S.
Kenya, Nairobi
Kenya Medical Research Institute
Lang, Trudie A.
United Kingdom, Oxford
University of Oxford
Mwangi, Tabitha Wanja
Kenya, Nairobi
Kenya Medical Research Institute
Gilbert, Sarah C.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Peshu, Norbert M.
Kenya, Nairobi
Kenya Medical Research Institute
Marsh, Kevin
Kenya, Nairobi
Kenya Medical Research Institute
United Kingdom, Oxford
Nuffield Department of Medicine
Hill, Adrian V. S.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 95
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.4049/jimmunol.179.6.4193
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya