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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Ugandan HIV-1 V3 loop sequences closely related to the U.S./European consensus
Virology, Volume 190, No. 2, Year 1992
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Description
The third variable (V3) loop of the human immunodeficiency virus type 1 (HIV-1) envelope protein is an important determinant for virus neutralization and cell tropism. V3 loop sequences from uncultured lymphocytes obtained in 1990 from 22 Ugandan HIV-1-infected patients could, with the exception of two patients' sequences, be divided into two groups (A and B) on the basis the V3 loop size and sequence. The V3 loop consensus sequences from both groups showed a high degree of homology to a U.S./European consensus, a characteristic also reflected by the results of peptide serology. In the case of group B the difference in sequence was only five amino acids. In contrast, the V3-flanking regions for both groups showed greater homology to an earlier (1986/1987) Ugandan consensus. The discovery of these two new Ugandan V3 loop genotypes, which are closely related to the U.S./European consensus, has implications for the understanding of the evolution of HIV-1 and for the future design of a vaccine for use in Africa. © 1992.
Authors & Co-Authors
Albert, Jan
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
Franzén, Lena
Sweden, Uppsala
Uppsala Universitet
Sweden, Stockholm
Karolinska Institutet
Jansson, Marianne
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
Sweden, Stockholm
Karolinska Institutet
SCARLATTI, GABRIELLA
Sweden, Stockholm
Karolinska Institutet
Italy, Milan
Università Degli Studi Di Milano
Kataaha, Peter K.
Uganda, Kampala
Nakasero Blood Bank
Katabira, Elly Tebasoboke
Uganda, Kampala
Makerere University
Mubiro, Francis
Uganda, Kampala
Makerere University
Rydåker, Maria
Sweden, Uppsala
Uppsala Universitet
Rossi, Paolo
Sweden, Uppsala
Uppsala Universitet
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Pettersson, Ulf
Sweden, Uppsala
Uppsala Universitet
Wigzell, Hans L.
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 37
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/0042-6822(92)90905-5
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Infectious Diseases