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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
History of illness prior to a diagnosis of bipolar disorder or schizoaffective disorder
Journal of Affective Disorders, Volume 103, No. 1-3, Year 2007
Notification
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Description
Background: There are obstacles to early identification of bipolar disorder. Identifying and treating illness early in its time course may be associated with a better prognosis. Methods: A questionnaire was administered at interview, when the participant was euthymic, to participants (n = 240) enrolled in the Bipolar Comprehensive Outcomes Study (BCOS). Information was collected about the sequential timeline of specific symptoms of mental illness up to when they first received a diagnosis of Bipolar Disorder or Schizoaffective Disorder. Results: Any symptoms of mental illness were first experienced at 17.5 years (median; Inter Quartile Range (IQR) 13.8-24.3; n = 216) and mood swings at 18.0 years (IQR 14-25; n = 197). Symptoms of depression were experienced at 18.0 years (IQR 14-25; n = 197), a full episode of depression at 21.2 years (IQR 17-28.5; n = 200), symptoms of mania at 21.0 years (IQR 16.8-29.5; n = 212) and a full episode of mania at 24.1 years (IQR 19-30.5; n = 205). Medical treatment was sought at 24.0 years (IQR 19-31.5; n = 217). Participants received a diagnosis of Bipolar Disorder or Schizoaffective Disorder at 30.0 years (IQR 23-37.3; n = 215). Having had a previous diagnosis other than Bipolar Disorder or Schizoaffective Disorder was reported by 120 of 216 participants who answered this question, most commonly unipolar depression (26.6%). Diagnostic delay was greater in individuals with early onset disorder. Conclusions: Participants typically experience a long sequential course of symptoms, episodes, treatments and diagnosis. The polarity of onset is most commonly depressive, and subthreshold symptoms tend to precede threshold symptoms of both polarities. Limitations: Data were collected retrospectively. © 2007 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Berk, Michael
Australia, Geelong
Barwon Health
Dodd, Seetal M.
Australia, Geelong
Barwon Health
Kulkarni, Jayashri
Australia, Clayton
Monash University
Statistics
Citations: 190
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.jad.2007.01.027
ISSN:
01650327
Research Areas
Mental Health