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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Modulation of COX, LOX and NFκB activities by Xanthium spinosum L. root extract and ziniolide
Fitoterapia, Volume 91, Year 2013
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Description
Xanthium spinosum L. (Asteraceae) is a medicinal weed distributed worldwide. Many of its diverse ethnopharmacological uses - namely diarrhoea, inflammation, liver disorders, snake bite and fever - are linked - at least in part - to an uncontrolled release of arachidonic acid metabolites. The crude extract of X. spinosum roots from Jordanian origin dose-dependently inhibited the 5-LOX (IC50 ≅ 10 μg/mL), COX-1(IC50 ≅ 50 μg/mL), and 12-LOX (IC50 ≅ 170 μg/mL) enzymatic pathways in intact pro-inflammatory cells. A direct activity at the level of PLA 2 is not probable, but the extract induced the synthesis of the anti-inflammatory eicosanoid 15(S)-HETE, which may in turn inhibit this enzyme. 5-LOX bioguided fractionation of the crude extract led to the isolation of ziniolide, a known 12,8-guaianolide sesquiterpene lactone, from the hydro-alcoholic fraction of the n-hexane extract (IC50 = 69 μM). Both the plant extract and ziniolide are in vitro inhibitors of the phorbol-induced NFκB activation, a key regulator of the arachidonic pathway. © 2013 Elsevier B.V.
Authors & Co-Authors
Bader, Ammar
Saudi Arabia, Makkah
Umm Al-qura University
Giner, R. M.
Spain, Valencia
Universitat de València
Martini, Francesca
Spain, Valencia
Universitat de València
Schinella, Guillermo R.
Spain, Valencia
Universitat de València
Argentina, La Plata
Comision de Investigaciones Cientificas - la Plata
Ŕios, José Luis
Spain, Valencia
Universitat de València
Braca, Alessandra
Italy, Pisa
Università Di Pisa
Prieto, José MarÃa
Spain, Valencia
Universitat de València
United Kingdom, London
Ucl School of Pharmacy
Statistics
Citations: 18
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/j.fitote.2013.09.015
ISSN:
0367326X
e-ISSN:
18736971
Research Areas
Infectious Diseases