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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The relationship between diagnostic tests and case characteristics in Legionnaires' disease
Scandinavian Journal of Infectious Diseases, Volume 41, No. 6-7, Year 2009
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Description
In this retrospective study of 332 cases of Legionnaires' disease (LD) in 4 Danish counties between 1995 and 2005 we aimed to compare the sensitivity of culture, PCR, urinary antigen testing, and serology to the mode of acquisition, serogroup, and severity of disease. Furthermore, we analyzed time to diagnosis. Laboratory confirmed cases of LD were found through the national Danish surveillance system and departments of clinical microbiology. In our study PCR was more sensitive (79.2%) than urinary antigen testing (70.4%), serology (54.8%), and culture (39.9%) (p<0.001).The sensitivity of Legionella urinary antigen test was higher among travel-associated cases (90.2%) compared to non-travel-associated cases (65.8%) and hospital acquired cases (45.7%) (p<0.001). Overall, the most common species and serogroup identified was L. pneumophila serogroup 1 (64.3% (110/171)). Community acquired cases with serogroup 1 were diagnosed earlier (mean 5 d, IQR: 49 d) than community acquired cases with other species or serogroups (mean 10.5 d, IQR: 519.5) (p<0.001). In conclusion, the urinary antigen test, PCR, and culture were conducive to the diagnosis of Legionella infection, and ordering of all 3 tests is recommended to ensure a definite and rapid diagnosis of Legionella. © 2009 Informa UK Ltd.
Authors & Co-Authors
Jespersen, Sanne
Denmark, Aarhus
Aarhus Universitetshospital
Søgaard, Ole S.
Denmark, Aarhus
Aarhus Universitetshospital
Østergaard, Lars Jørgen
Denmark, Aarhus
Aarhus Universitetshospital
Statistics
Citations: 14
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1080/00365540902946536
ISSN:
16511980
Research Areas
Health System And Policy
Study Design
Cohort Study