Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Capripoxvirus G-protein-coupled chemokine receptor: A host-range gene suitable for virus animal origin discrimination
Journal of General Virology, Volume 90, No. 8, Year 2009
Notification
URL copied to clipboard!
Description
The genus Capripoxvirus within the family Poxviridae comprises three closely related viruses, namely goat pox, sheep pox and lumpy skin disease viruses. This nomenclature is based on the animal species from which the virus was first isolated, respectively, goat, sheep and cattle. Since capripoxviruses are serologically identical, their specific identification relies exclusively on the use of molecular tools. We describe here the suitability of the G-protein-coupled chemokine receptor (GPCR) gene for use in host-range grouping of capripoxviruses. The analysis of 58 capripoxviruses showed three tight genetic clusters consisting of goat pox, sheep pox and lumpy skin disease viruses. However, a few discrepancies exist with the classical virus-host origin nomenclature: a virus isolated from sheep is grouped in the goat poxvirus clade and vice versa. Intra-group diversity was further observed for the goat pox and lumpy skin disease virus isolates. Despite the presence of nine vaccine strains, no genetic determinants of virulence were identified on the GPCR gene. For sheep poxviruses, the addition or deletion of 21 nucleic acids (7 aa) was consistently observed in the 59 terminal part of the gene. Specific signatures for each cluster were also identified. Prediction of the capripoxvirus GPCR topology, and its comparison with other known mammalian GPCRs and viral homologues, revealed not only a classical GPCR profile in the last three-quarters of the protein but also unique features such as a longer N-terminal end with a proximal hydrophobic α-helix and a shorter serine-rich C-tail. © 2009 SGM.
Authors & Co-Authors
Le Goff, Christian
France, Paris
Cirad
Lamien, Charles Euloge
Austria, Vienna
International Atomic Energy Agency, Vienna
Fakhfakh, Emna
Tunisia, Tunis
Institut de Recherche Vétérinaire de Tunis
Chadeyras, Amĺie
France, Paris
Cirad
Aba-Adulugba, Elexpeter P.
Nigeria, Vom
National Veterinary Research Institute, Vom
Libeau, Geneviève
France, Paris
Cirad
Tuppurainen, Eeva S.M.
United Kingdom, Surrey
The Pirbright Institute
Wallace, David Brian
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
South Africa, Pretoria
University of Pretoria
Adam, Tajelser
Sudan, Khartoum
Central Veterinary Research Laboratory Sudan
Silber, Roland
Austria, Vienna
Austrian Agency for Health and Food Safety
Gulyaz, Verý
Turkey, Pendik
Pendik Veteriner Kontrol ve Arastirma Enstitüsü
Madani, Hafsa
Algeria, Algiers
École Nationale Supérieure Vétérinaire D'alger
Caufour, Philippe S.
France, Paris
Cirad
Hammami, Salah
Tunisia, Tunis
Institut de Recherche Vétérinaire de Tunis
Diallo, Adama
Austria, Vienna
International Atomic Energy Agency, Vienna
Albina, Emmanuel
France, Paris
Cirad
Statistics
Citations: 142
Authors: 16
Affiliations: 11
Identifiers
Doi:
10.1099/vir.0.010686-0
ISSN:
00221317
e-ISSN:
14652099
Research Areas
Genetics And Genomics