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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pre-onset risk characteristics for mania among young people at clinical high risk for psychosis
Schizophrenia Research, Volume 192, Year 2018
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Description
Introduction: Psychosis and mania share conceptual, genetic and clinical features, which suggest the possibility that they have common antecedents. Participants identified to be at-risk for psychosis might also be at-risk for mania. We aimed to identify the rate and predictors of transition to mania in a cohort of youth with clinical or familial risk for psychosis. Methods: Among a cohort of 416 young people with an at-risk mental state for psychosis defined using the Ultra-High-Risk (UHR) criteria, 74.7% were followed up between 5 and 13 years from their baseline assessment. We undertook a matched case-control examination of those who developed mania over the follow-up period compared to those who did not develop mania or psychosis. Transition to mania was determined using either a structured clinical interview, or diagnoses from a state-wide public mental health contact registry. Clinical characteristics and risk factors were examined at baseline using information from structured interviews, clinical file notes, rating scales and unstructured assessments. Results: Eighteen participants developed mania (UHR-Manic transition or UHR-M, 4.3%). In comparison with participants matched on age, gender and baseline-study who developed neither mania nor psychosis, more UHR-M participants had subthreshold manic symptoms or were prescribed antidepressants at baseline. They also had lower global functioning. Discussion: In addition to the UHR criteria, features such as subthreshold manic symptoms and antidepressant use may help identify at-risk groups that predict the onset of mania in addition to transition to psychosis. Presence of manic symptoms may also indicate syndrome specificity early in the prodromal phase. © 2017 Elsevier B.V.
Authors & Co-Authors
Cotton, Sue M.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Davey, Christopher G.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Lin, Ashleigh
Australia, Perth
The University of Western Australia
Bechdolf, Andreas
Germany, Berlin
Vivantes Klinikum am Urban
McGorry, Patrick D.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Yung, Alison R.
United Kingdom, Manchester
Faculty of Biology, Medicine and Health
Berk, Michael
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
The Florey
Australia, Geelong
Barwon Health
Nelson, Barnaby
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Statistics
Citations: 7
Authors: 8
Affiliations: 8
Identifiers
Doi:
10.1016/j.schres.2017.04.036
ISSN:
09209964
Research Areas
Genetics And Genomics
Mental Health
Substance Abuse
Study Design
Cohort Study
Case-Control Study