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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus
Arthritis and Rheumatology, Volume 67, No. 8, Year 2015
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Description
Objective Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. Therefore, interest in blood HCQ concentration measurement has increased, but little is known about factors that influence blood HCQ concentration variability. This study was undertaken to analyze determinants of blood HCQ concentrations. Methods We conducted a retrospective analysis of patient data, including data from the Plaquenil Lupus Systemic (PLUS) study, to determine the association of epidemiologic, clinical, and biologic factors with blood HCQ concentrations. Data for nonadherent patients (blood HCQ concentration <200 ng/ml) were excluded. Results To examine homogeneous pharmacologic data, we restricted the analyses of the PLUS data to the 509 SLE patients receiving 400 mg/day. We found no association of ethnicity or smoking with blood HCQ concentrations and no pharmacokinetic drug-drug interaction with antacids or with inhibitors or inducers of cytochrome P450 enzymes. On multivariate analysis, high body mass index (P=0.008), no treatment with corticosteroids (P=0.04), increased time between the last tablet intake and measurement of blood HCQ concentrations (P=0.017), low platelet count (P < 0.001), low neutrophil count (P < 0.001), and high estimated creatinine clearance (P < 0.001) were associated with low blood HCQ concentrations. In 22 SLE patients with chronic renal insufficiency (median serum creatinine clearance 52 ml/minute [range 23-58 ml/minute]) who received 400 mg/day HCQ, the median blood HCQ concentration was significantly higher than that in the 509 patients from the PLUS study (1,338 ng/ml [range 504-2,229 ng/ml] versus 917 ng/ml [range 208-3316 ng/ml]) (P < 0.001). Conclusion We provide a comprehensive analysis of determinants of blood HCQ concentrations. Because this measurement is increasingly being used, these data might be useful for clinicians. © 2015, American College of Rheumatology.
Authors & Co-Authors
Jallouli, Moez
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Galicier, Lionel
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Aumaìtre, Olivier
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
Françès, Carnille
France, Paris
Hôpital Tenon
Le-Guern, Véronique
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Smaïl, Amar
France, Amiens
Chu Amiens Picardie
Limal, Nicolas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Pérard, Laurent
France, Lyon
Chu de Lyon
Desmurs-Clavel, Hélène
France, Lyon
Chu de Lyon
Lê Thi Huong, Du
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Asli, Bouchra
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Kahn, Jean Emmanuel
France, Suresnes
Hopital Foch
Pourrat, Jacques P.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Sailler, Laurent J.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Ackermann, Félix
France, Suresnes
Hopital Foch
Papo, Thomas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Sacré, Karim
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Fain, Olivier
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Stirnemann, Jérôme
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Cacoub, Patrice P.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Leroux, Gaëlle D.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Cohen-Bittan, Judith
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Sellam, Jérémie A.A.
France, Paris
Centre de Recherche Saint-antoine
Mariette, Xavier
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Blanchet, Benoît
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Hulot, Jean Sebastien
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Amoura, Zahir
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Piette, Jean Charles
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
CostéDoat-Chalumeau, Nathalie
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Statistics
Citations: 111
Authors: 29
Affiliations: 9
Identifiers
Doi:
10.1002/art.39194
ISSN:
23265191
Research Areas
Health System And Policy
Study Design
Cohort Study