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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Prevalence of PCR detectable malaria infection among febrile patients with a negative plasmodium falciparum specific rapid diagnostic test in Zanzibar
American Journal of Tropical Medicine and Hygiene, Volume 88, No. 2, Year 2013
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Description
We screened for malaria in 594 blood samples from febrile patients who tested negative by a Plasmodium falciparum-specific histidine-rich protein-2-based rapid diagnostic test at 12 health facilities in Zanzibar districts North A and Micheweni, from May to August 2010. Screening was with microscopy, polymerase chain reaction (PCR) targeting the cytochrome b gene (cytbPCR) of the four major human malaria species, and quantitative PCR (qPCR). The prevalence of cytbPCR-detectable malaria infection was 2% (12 of 594), including 8 P. falciparum, 3 Plasmodium malariae, and 1 Plasmodium vivax infections. Microscopy identified 4 of 8 P. falciparum infections. Parasite density as estimated by microscopy or qPCR was > 4,000 parasites/mL in 5 of 8 cytbPCR-detectable P. falciparum infections. The infections that were missed by the rapid diagnostic test represent a particular challenge in malaria elimination settings and highlight the need for more sensitive point-of-care diagnostic tools to improve case detection of all human malaria species in febrile patients. Copyright © 2013 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Baltzell, Kimberly A.
United States, San Francisco
University of California, San Francisco
Shakely, Delér
Sweden, Stockholm
Karolinska Institutet
Hsiang, Michelle S.
United States, San Francisco
University of California, San Francisco
Kemere, Jordan
United States, Chapel Hill
Unc School of Medicine
Ali, Abdullah Suleiman
Tanzania, Mkokotoni
Ministry of Health Zanzibar
Bjǒrkman, Anders B.
Sweden, Stockholm
Karolinska Institutet
Mårtensson, Andreas A.
Sweden, Stockholm
Karolinska Institutet
Omar, Rahila S.
Tanzania, Mkokotoni
Ministry of Health Zanzibar
Elfving, Kristina
Sweden, Stockholm
Karolinska Institutet
Msellem, Mwinyi I.
Tanzania, Mkokotoni
Ministry of Health Zanzibar
Aydin-Schmidt, Berit
Sweden, Stockholm
Karolinska Institutet
Rosenthal, Philip Jon
United States, San Francisco
Ucsf School of Medicine
Greenhouse, Bryan R.
United States, San Francisco
Ucsf School of Medicine
Statistics
Citations: 34
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2012.12-0095
ISSN:
00029637
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative