Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Fludarabine-Based Conditioning Chemotherapy for Allogeneic Hematopoietic Stem Cell Transplantation in Acquired Severe Aplastic Anemia
Biology of Blood and Marrow Transplantation, Volume 17, No. 5, Year 2011
Notification
URL copied to clipboard!
Description
Thirty-eight patients who met the diagnostic criteria for severe aplastic anemia underwent allogeneic hematopoietic stem cell transplantation (HSCT). The median patient age was 20 years (range, 14-36 years). Twenty-four patients were treatment-naïve, 11 had failed one or more previous courses of immunosuppressive therapy, and 3 had failed a previous HSCT. The conditioning regimen included fludarabine 30 mg/m2/day for 3 days (days -9, -8, and -7) and cyclophosphamide 50 mg/kg/day for 4 days (days -5, -4, -3, and -2). Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and short-course methotrexate. All patients underwent transplantation with unmanipulated bone marrow as the stem cell source. The median total nucleated cell (TNC) dose was 2.43 × 108/kg (range, 0.60-6.7 × 108/ kg). The conditioning regimen was well tolerated, with minimal treatment-related mortality. Engraftment was observed in all patients after transplantation; the median time to engraftment of neutrophils and platelets was 18 and 23 days, respectively. Twenty-five of the 27 patients with available chimeric studies at day 180 maintained donor chimerism. Acute GVHD grade ≥II was diagnosed in 4 patients (11%). Extensive chronic GVHD was observed in 8 patients (25%) who survived beyond day +100, at a median observation time of 43 months. Graft rejection with relapse of aplais was observed in one patient. The overall survival (OS) for the whole group was 79%. A trend toward improved OS was observed in the treatment-naïve patients (83% vs 71%), but this was statistically insignificant (P = .384). The fludarabine-based conditioning regimen used in this study with relatively young cohort of patients was well tolerated, with a low rate of rejection and treatment outcomes comparable to those seen in other, more intense and potentially more toxic conditioning regimens. Our results await validation in a larger study, optimally in a randomized controlled manner. © 2011 American Society for Blood and Marrow Transplantation.
Authors & Co-Authors
Al-Zahrani, Hazzaa Abdulla
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Nassar, Amr
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Mohareb, Fahad I.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Sharif, Fahad Z.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Mohamed, Said Yousuf
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Anazi, Khalid Ahmed
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Patel, Moosa
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Rasheed, Walid
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Saleh, Abu Jafar Mohammed
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Bakr, Mohammad Mahmoud
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ahmed, Shad O.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ibrahim, Khalid El Tayeb
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Hussain, Fazal
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Elkum, Naser
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Elhassan, Tusneem A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Nurgat, Zubeir A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Chaudhri, Naeem Arshad
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Aljurf, Mahmoud Deeb
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 22
Authors: 18
Affiliations: 1
Identifiers
Doi:
10.1016/j.bbmt.2010.08.013
ISSN:
10838791
e-ISSN:
15236536
Research Areas
Cancer
Environmental
Health System And Policy
Study Design
Cohort Study