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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Crucial role of gamma interferon-producing CD4
+
Th1 cells but dispensable function of cd8
+
t cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice
Infection and Immunity, Volume 80, No. 12, Year 2012
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Description
Brucella spp. are facultative intracellular bacterial pathogens responsible for brucellosis, a worldwide zoonosis that causes abortion in domestic animals and chronic febrile disease associated with serious complications in humans. There is currently no approved vaccine against human brucellosis, and antibiotic therapy is long and costly. Development ofa safe protective vaccine requires a better understanding of the roles played by components of adaptive immunity in the control of Brucella infection. The importance of lymphocyte subsets in the control of Brucella growth has been investigated separately by various research groups and remains unclear or controversial. Here, we used a large panel of genetically deficient mice to compare the importance of B cells, transporter associated with antigen processing (TAP-1), and major histocompatibility complex class II-dependent pathways of antigen presentation as well as T helper 1 (Th1), Th2, and Th17-mediated responses on the immune control of Brucella melitensis 16Minfection. We clearly confirmed the key function played by gamma interferon (IFN-γ)-producing Th1 CD4+ T cells in the control of B. melitensis infection, whereas IFN-γ-producing CD8+ T cells or B cell-mediated humoral immunity plays only a modest role in theclearance of bacteria during primary infection. In the presence of a Th1 response, Th2 or Th17 responses do not really develop or play a positiveor negative role during the course of B. melitensis infection. On the whole, these results could improve our ability to develop protective vaccines or therapeutic treatments against brucellosis. © 2012, AmericanSociety for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3497404/bin/supp_80_12_4271__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3497404/bin/IAI.00761-12_zii999099906so1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3497404/bin/IAI.00761-12_zii999099906so2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3497404/bin/IAI.00761-12_zii999099906so3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3497404/bin/IAI.00761-12_zii999099906so4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3497404/bin/IAI.00761-12_zii999099906so5.pdf
Authors & Co-Authors
Vitry, Marie Alice
Belgium, Namur
Namur Research Institute for Life Sciences
Trez, Carl De
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Goriely, Stanislas
Belgium, Brussels
Université Libre de Bruxelles
Dumoutier, Laure
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Akira, Shizuo
Japan, Suita
Research Institute for Microbial Diseases
Ryffel, Bernhard
South Africa, Cape Town
University of Cape Town
Carlier, Yves
Belgium, Brussels
Université Libre de Bruxelles
Letesson, Jean J. J.
Belgium, Namur
Namur Research Institute for Life Sciences
Muraille, Eric
Belgium, Brussels
Université Libre de Bruxelles
Statistics
Citations: 94
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1128/IAI.00761-12
ISSN:
00199567
e-ISSN:
10985522
Research Areas
Infectious Diseases
Sexual And Reproductive Health