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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Bioactive compounds from Rumex plants
Phytochemistry Letters, Volume 3, No. 4, Year 2010
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Description
Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15-25) were evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines. The results showed that compound 15 was the most active against M. tuberculosis with an MIC value of 2.85 μM similar to that of isoniazid. Compound 5 could inhibit pAba synthetic pathway with an MIC value of 12.6 μM, comparable to that of positive control abyssomicin C, representing a new example of the rare pAba pathway inhibitors. © 2010 Phytochemical Society of Europe.
Authors & Co-Authors
Dai, Huanqin
China, Beijing
Institute of Microbiology Chinese Academy of Sciences
Adebayo, Abiodun Humphrey
China, Beijing
Chinese Academy of Sciences
Zhang, Lixin
China, Beijing
Institute of Microbiology Chinese Academy of Sciences
Statistics
Citations: 56
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.phytol.2010.05.005
ISSN:
18743900
Research Areas
Cancer