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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Y-chromosome AZFc structural architecture and relationship to male fertility
Fertility and Sterility, Volume 92, No. 6, Year 2009
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Description
Objective: To determine if there is a relationship between various forms of partial AZFc deletions and spermatogenic failure. Design: Case-control study. Setting: Infertility clinic (Tenon Hospital, Paris). Patient(s): 557 men, comprising 364 infertile men from mixed ethnic backgrounds, and 193 men with known fertility (n = 84) and/or normospermic (n = 109). Intervention(s): Characterization of 32 partial AZFc deletions. Main Outcome Measure(s): DAZ gene cluster divided into two families (DAZ1/2 and DAZ3/4), CDY1 gene, and Y-chromosome haplogroups. Result(s): We observed 18 partial AZFc deletions in 364 (4.95%) infertile men compared with 14 out of 193 (7.25%) in the control normospermic/fertile group. Conclusion(s): The analysis of informative Y-chromosome single nucleotide variants combined with Y-chromosome haplogroup definition enabled us to infer seven deletion classes that occur on a minimum of six Y-chromosome parental architectures. We found no relationship between either the presence or the absence of DAZ1/2, DAZ3/4, CDY1a, or CDY1b with spermatogenic failure at least on one Y-chromosome lineage. The DAZ dosage and Southern blot analyses indicated that the majority of individuals tested carried two copies of the DAZ gene, indicating a partial AZFc deletion. Our data are consistent with the hypothesis that, at least in our study populations, partial AZFc deletions may have a limited impact on fertility. © 2009.
Authors & Co-Authors
Ravel, Célia
France, Paris
Institut Pasteur, Paris
France, Paris
Sorbonne Université
France, Paris
Hôpital Tenon
Chantot-Bastaraud, Sandra
France, Paris
Institut Pasteur, Paris
France, Paris
Sorbonne Université
France, Paris
Hôpital Armand-trousseau
El Houate, B.
Morocco, Casablanca
Institut Pasteur du Maroc
Rouba, Hassan
Morocco, Casablanca
Institut Pasteur du Maroc
Legendre, Marie
France, Paris
Hôpital Armand-trousseau
Lorenço, Diana
France, Paris
Institut Pasteur, Paris
France, Paris
Sorbonne Université
Mandelbaum, Jacqueline
France, Paris
Sorbonne Université
France, Paris
Hôpital Tenon
Siffroi, Jean Pierre
France, Paris
Sorbonne Université
France, Paris
Hôpital Armand-trousseau
McElreavey, Ken D.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 35
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.fertnstert.2008.08.135
ISSN:
00150282
Research Areas
Genetics And Genomics
Health System And Policy
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Case-Control Study
Participants Gender
Male