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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The calculated genetic barrier for antiretroviral drug resistance substitutions is largely similar for different HIV-1 subtypes
Journal of Acquired Immune Deficiency Syndromes, Volume 41, No. 3, Year 2006
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Description
Background: The genetic barrier, defined as the number of mutations required to overcome drug-selective pressure, is an important factor for the development of HIV drug resistance. Because of high variability between subtypes, particular HIV-1 subtypes could have different genetic barriers for drug resistance substitutions. This study compared the genetic barrier between subtypes using some 2000 HIV-1 sequences (>600 of non-B subtype) isolated from antiretroviral-naive patients in Europe. Methods: The genetic barrier was calculated as the sum of transitions (scored as 1) and/or transversions (2.5) required for evolution to any major drug resistance substitution. In addition, the number of minor protease substitutions was determined for every subtype. Results: Few dissimilarities were found. An increased genetic barrier was calculated for I82A (subtypes C and G), V108I (subtype G), V118I (subtype G), Q151M (subtypes D and F), L210W (subtypes C, F, G, and CRF02_AG), and P225H (subtype A) (P < 0.001 compared with subtype B). A decreased genetic barrier was found for I82T (subtypes C and G) and V106M (subtype C) (P < 0.001 vs subtype B). Conversely, minor protease substitutions differed extensively between subtypes. Conclusions: Based on the calculated genetic barrier, the rate of drug resistance development may be similar for different HIV-1 subtypes. Because of differences in minor protease substitutions, protease inhibitor resistance could be enhanced in particular subtypes once the relevant major substitutions are selected. Copyright © 2006 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Van De Vijver, D. A.M.C.
Netherlands, Utrecht
Eijkman-winkler Center for Microbiology, Infectious Diseases and Inflammation Univeristy Medical Center Utrecht
Wensing, Annemarie Marie J.
Netherlands, Utrecht
Eijkman-winkler Center for Microbiology, Infectious Diseases and Inflammation Univeristy Medical Center Utrecht
Netherlands, Utrecht
University Medical Center Utrecht
Angarano, Gioacchino
Italy, Foggia
Università Degli Studi Di Foggia
Åsjö, Birgitta
Norway, Bergen
Universitetet I Bergen
Balotta, Claudia
Italy, Milan
Università Degli Studi Di Milano
Boeri, Enzo
Unknown Affiliation
Camacho, Ricardo Jorge
Unknown Affiliation
Chaix, Marie Laure
France, Paris
Hôpital Necker Enfants Malades
Costagliola, Dominique G.
France, Paris
Hôpital Universitaire Pitié Salpêtrière
De Luca, Andrea
Unknown Affiliation
Derdelinckx, Inge
Belgium, Leuven
Ku Leuven
Grossman, Zehava
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Hamouda, Osamah
Germany, Berlin
Robert Koch Institute
Hatzakis, Angelos E.
Greece, Athens
School of Medicine
Hemmer, Robert J.P.
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Hoepelman, Andy I.M.
Netherlands, Utrecht
University Medical Center Utrecht
Horban, Andrzéj
Unknown Affiliation
Korn, Klaus
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Kücherer, Claudia
Germany, Berlin
Robert Koch Institute
Leitner, Thomas K.
United States, Los Alamos
Los Alamos National Laboratory
Loveday, Clive
Unknown Affiliation
de-Mendoza, Carmen
Unknown Affiliation
Meyer, Laurence J.
France, Paris
Inserm
Nielsen, Claus M.
Denmark, Copenhagen
Statens Serum Institut
Ormaasen, Vidar
Norway, Oslo
Ulleval University Hospital
Paraskevis, D. N.
Greece, Athens
School of Medicine
Perrin, Luc Henri
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Puchhammer-Stöckl, Elisabeth
Austria, Vienna
Universität Wien
Ruíz, Lídia
Unknown Affiliation
Salminen, Mika O.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Schmit, Jean Claude
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Schneider, François
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Schuurman, Rob J.
Netherlands, Utrecht
Eijkman-winkler Center for Microbiology, Infectious Diseases and Inflammation Univeristy Medical Center Utrecht
Soriano, Vicente Vicente
Unknown Affiliation
Stanojevic, Maja
Serbia, Belgrade
University of Belgrade
Vandamme, Anne Mieke
Belgium, Leuven
Ku Leuven
van Laethem, Kristel V.
Belgium, Leuven
Ku Leuven
Yerly, Sabine T.B.D.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Zazzi, Maurizio
Italy, Siena
Università Degli Studi Di Siena
Boucher, Charles A.B.
Netherlands, Utrecht
Eijkman-winkler Center for Microbiology, Infectious Diseases and Inflammation Univeristy Medical Center Utrecht
Netherlands, Utrecht
University Medical Center Utrecht
Statistics
Citations: 89
Authors: 40
Affiliations: 24
Identifiers
Doi:
10.1097/01.qai.0000209899.05126.e4
ISSN:
15254135
Research Areas
Genetics And Genomics
Infectious Diseases