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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cost-effectiveness of on-site antenatal screening to prevent congenital syphilis in rural Eastern Cape Province, Republic of South Africa
Sexually Transmitted Diseases, Volume 34, No. 7 SUPPL., Year 2007
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Description
OBJECTIVES: On-site screening and same-day treatment of maternal syphilis in underresourced settings can avert greater numbers of congenital syphilis cases, but health outcomes and associated costs must be evaluated jointly. METHODS: We used decision analysis to estimate the incremental cost-effectiveness of two on-site antenatal syphilis screening strategies to avert congenital infections-qualitative RPR (on-site RPR) and treponemal immunochromatographic strip assay (on-site ICS)-compared to the current practice (off-site RPR/TPHA). FINDINGS: With antenatal active syphilis prevalence of 6.3%, the incremental cost-effectiveness of on-site ICS in averting congenital infections was estimated to be USD104, averting 82% of cases expected in absence of a program. The incremental cost-effectiveness of off-site RPR/TPHA was USD82 but would avert only 55% of congenital syphilis cases. On-site RPR was dominated by the other screening strategies. CONCLUSIONS: In settings of high maternal syphilis prevalence, on-site antenatal screening with ICS is a cost-effective approach to reduce the incidence of congenital syphilis. © Copyright 2007 American Sexually Transmitted Diseases Association.
Authors & Co-Authors
Blandford, John M.
United States, Atlanta
Centers for Disease Control and Prevention
Gift, Thomas L.
United States, Atlanta
Centers for Disease Control and Prevention
Vasaikar, Sandeep
South Africa
University of Transkei (unitra)
Mwesigwa-Kayongo, Dan
South Africa
University of Transkei (unitra)
Dlali, Pumla
South Africa
University of Transkei (unitra)
Bronzan, Rachel N.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 52
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1097/01.olq.0000258314.20752.5f
ISSN:
01485717
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Qualitative
Study Locations
South Africa