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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Avascular osteonecrosis of the femoral head in three West African HIV-infected adults with heterozygous sickle cell disease
Antiviral Therapy, Volume 14, No. 7, Year 2009
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Description
Three men (aged 33, 44 and 45 years, CD4+ T-cell nadir 86 cells/mm3, 99 cells/mm3 and 12 cells/mm3, respectively) were admitted to the Department of Infectious Diseases (Treichville Hospital, Abidjan, Côte d'Ivoire) for hip pain and impaired mobility. Their last available CD4+ T-cell counts were 243 cells/mm3, 245 cells/ mm3 and 8 cells/mm3, respectively. They had all received antiretroviral therapy for >4 years, including lopinavir/ ritonavir for >8 months. The other risk factors were hypertriglyceridaemia (n=3), smoking addiction (n=2), alcohol consumption (n=2) and lipodystrophy (n=1). All three patients had heterozygous haemoglobin AS sickle cell disease (percentage of haemoglobin S 41%, 45% and 50%, respectively). The diagnosis of avascular osteonecrosis of the femoral head (unilateral n=2 and bilateral n=1) was documented by CT scan. Only one patient underwent surgical arthroplasty. In resource-limited settings, avascular osteonecrosis is uneasy to diagnose and unlikely to be appropriately treated. Physicians should be aware of its symptoms and risk factors, including HIV infection and antiretroviral therapy. Future studies should explore whether these risk factors might include haemoglobin AS sickle cell disease, a common trait in the West African general population. ©2009 International Medical Press.
Authors & Co-Authors
Eholié, Serge Paul
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Cote D'ivoire, Abidjan
Programme Pac-ci
Ouiminga, Mariama
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Ehui, Eboi
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Nzunetu, Gustave
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Ouattara, Ismaèl Songda
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Konan, Alexis Victorien
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Anglaret, Xavier
Cote D'ivoire, Abidjan
Programme Pac-ci
France, Paris
Inserm
Bissagnéné, Emmanuel
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Statistics
Citations: 10
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.3851/IMP1398
ISSN:
13596535
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Substance Abuse
Study Design
Cross Sectional Study
Study Locations
Ivory Coast
Participants Gender
Male