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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Factors influencing susceptibility to meningococcal disease during an epidemic in The Gambia, West Africa
Journal of Infection, Volume 14, No. 2, Year 1987
Notification
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Description
A study was made of factors that influenced susceptibility to group A meningococcal disease during an epidemic that affected The Gambia, West Africa during the dry season of 1982-83. No explanations were found for the distribution of cases between villages or within affected villages. Socio-economic status, crowding, nutrition and previous exposure to meningococcal disease all appeared to be unimportant. Examination of serum samples obtained before the outbreak from a few children who subsequently became patients and from an equal number of age-matched controls from the same village showed a higher mean serum IgA value in children who became patients than in controls. There were not, however, any significant differences found in the concentrations of IgG, IgM, complement or meningococcal antibody between the two groups. Four children who developed culture-proven group A meningococcal disease had raised titres of bactericidal antibody to the epidemic strain 2-3 months before their illnesses. Our findings suggest that some important risk factors for group A meningococcal disease remain to be identified. © 1987 The British Society for the Study of Infection.
Authors & Co-Authors
Greenwood, Brian M.
Unknown Affiliation
Greenwood, Alice M.
Unknown Affiliation
Bradley, A. K.
Unknown Affiliation
Williams, K.
Unknown Affiliation
Hassan-King, Musa K.A.
Unknown Affiliation
Shenton, F. C.
Unknown Affiliation
Wall, Robert A.
Unknown Affiliation
Hayes, Richard John
Unknown Affiliation
Statistics
Citations: 69
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/S0163-4453(87)92052-4
ISSN:
01634453
Research Areas
Food Security
Maternal And Child Health
Study Locations
Multi-countries
Gambia