Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
Nature Medicine, Volume 1, No. 10, Year 1995
Notification
URL copied to clipboard!
Description
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent. In follow–up studies conducted with athymic mice carrying human melanomas, tumour growth was completely inhibited without toxicity. As judged by a variety of cellular responses, antitumour activity was mediated by the induction of apoptosis. Betulinic acid is inexpensive and available in abundant supply from common natural sources, notably the bark of white birch trees. The compound is currently undergoing preciinicai development for the treatment or prevention of malignant melanoma. © 1995 Nature Publishing Group.
Authors & Co-Authors
Pisha, Emily
United States, Chicago
University of Illinois at Chicago
Chai, Heebyung
United States, Chicago
University of Illinois at Chicago
Lee, Iksoo
United States, Chicago
University of Illinois at Chicago
Chagwedera, Tangai Edwin
Zimbabwe, Harare
University of Zimbabwe
Farnsworth, Norman R.
United States, Chicago
University of Illinois at Chicago
Cordell, Geoffrey A.
United States, Chicago
University of Illinois at Chicago
Beecher, Christopher Wm W.
United States, Chicago
University of Illinois at Chicago
Fong, Harry H.S.
United States, Chicago
University of Illinois at Chicago
Kinghorn, A. Douglas
United States, Chicago
University of Illinois at Chicago
Brown, Daniel M.
United States, Research Triangle Park
Rti International
United States, New York
Bristol-myers Squibb
Wani, Mansukhlal C.
United States, Research Triangle Park
Rti International
Wall, Monroe E.
United States, Research Triangle Park
Rti International
Hieken, Tina J.
United States, Chicago
University of Illinois College of Medicine
Gupta, Tapas K.Das
United States, Chicago
University of Illinois College of Medicine
Pezzuto, John M.
United States, Chicago
University of Illinois at Chicago
United States, Chicago
University of Illinois College of Medicine
Statistics
Citations: 823
Authors: 15
Affiliations: 5
Identifiers
Doi:
10.1038/nm1095-1046
ISSN:
10788956
e-ISSN:
1546170X
Research Areas
Cancer