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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi
Journal of Infectious Diseases, Volume 204, No. 7, Year 2011
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Description
Background. BCG vaccination of infants is thought to provide good protection in all settings. This study investigated whether Malawian infants made weaker responses across a cytokine panel after BCG vaccination, compared with UK infants. Methods. Diluted whole-blood samples were cultured with Mycobacterium tuberculosis purified protein derivative for 6 days from BCG-vaccinated infants 3 months (n = 40 Malawi, 28 UK) and 12 months (n = 34 Malawi, 26 UK) after vaccination, and also from UK unvaccinated infants (n = 9 at 3 months, n = 10 at 12 months). Forty-two cytokines were measured in supernatants using a multiplex bead array assay. Principal component analysis was used to summarize the overall patterns in cytokine responses. Results. We found differences in median responses in 27 of the 42 cytokines: 7 higher in the UK and 20 higher in Malawi. The cytokines with higher responses in the UK were all T helper 1 related. The cytokines with higher responses in Malawi included innate proinflammatory cytokines, regulatory cytokines, interleukin 17, T helper 2 cytokines, chemokines, and growth factors. Principal component analysis separated the BCG-vaccinated infants from Malawi from the UK vaccinated infants and from the unvaccinated infants. Conclusions. Malawian infants make cytokine responses following BCG vaccination, but the cytokine profile is different from that in the UK. The different biosignatures following BCG vaccination in the 2 settings may indicate variability in the protective efficacy of infant BCG vaccination. © The Author 2011.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3164434/bin/supp_204_7_1075__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3164434/bin/supp_jir515_Supplementary_Table3_150311.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3164434/bin/supp_jir515_Supplementary_Table4_270211.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3164434/bin/supp_jir515_Supplementary_Table5_270211.doc
Authors & Co-Authors
Lalor, Maeve K.
Unknown Affiliation
Floyd, Sian
Unknown Affiliation
Gorak-Stolinska, Patricia M.A.
Unknown Affiliation
Ben-Smith, Anne W.
Unknown Affiliation
Weir, Rosemary E.
Unknown Affiliation
Smith, Steven G.
Unknown Affiliation
Newport, Melanie J.
Unknown Affiliation
Blitz, Rose
Unknown Affiliation
Mvula, Hazzie
Unknown Affiliation
Branson, Keith
Unknown Affiliation
McGrath, Nuala M.
Unknown Affiliation
Crampin, Amelia Catharine
Unknown Affiliation
Fine, Paul E.M.
Unknown Affiliation
Dockrell, Hazel M.
Unknown Affiliation
Statistics
Citations: 116
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/jir515
ISSN:
00221899
Research Areas
Maternal And Child Health
Study Locations
Malawi