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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical predictors of response to cognitive-behavioral therapy in pediatric anxiety disorders: The genes for treatment (GxT) study
Journal of the American Academy of Child and Adolescent Psychiatry, Volume 54, No. 6, Year 2015
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Description
Objective The Genes for Treatment study is an international, multisite collaboration exploring the role of genetic, demographic, and clinical predictors in response to cognitive-behavioral therapy (CBT) in pediatric anxiety disorders. The current article, the first from the study, examined demographic and clinical predictors of response to CBT. We hypothesized that the child's gender, type of anxiety disorder, initial severity and comorbidity, and parents' psychopathology would significantly predict outcome. Method A sample of 1,519 children 5 to 18 years of age with a primary anxiety diagnosis received CBT across 11 sites. Outcome was defined as response (change in diagnostic severity) and remission (absence of the primary diagnosis) at each time point (posttreatment, 3-, 6-, and/or 12-month follow-up) and analyzed using linear and logistic mixed models. Separate analyses were conducted using data from posttreatment and follow-up assessments to explore the relative importance of predictors at these time points. Results Individuals with social anxiety disorder (SoAD) had significantly poorer outcomes (poorer response and lower rates of remission) than those with generalized anxiety disorder (GAD). Although individuals with specific phobia (SP) also had poorer outcomes than those with GAD at posttreatment, these differences were not maintained at follow-up. Both comorbid mood and externalizing disorders significantly predicted poorer outcomes at posttreatment and follow-up, whereas self-reported parental psychopathology had little effect on posttreatment outcomes but significantly predicted response (although not remission) at follow-up. Conclusion SoAD, nonanxiety comorbidity, and parental psychopathology were associated with poorer outcomes after CBT. The results highlight the need for enhanced treatments for children at risk for poorer outcomes. © 2015 American Academy of Child and Adolescent Psychiatry.
Authors & Co-Authors
Hudson, Jennifer L.
Australia, Macquarie Park
The Faculty of Medicine, Health and Human Sciences
Keers, R.
United Kingdom, London
Faculty of Life Sciences & Medicine
Roberts, Susanna
United Kingdom, London
Faculty of Life Sciences & Medicine
Coleman, Jonathan R.I.
United Kingdom, London
Faculty of Life Sciences & Medicine
Breen, Gerome D.
United Kingdom, London
Faculty of Life Sciences & Medicine
Arendt, Kristian Bech
Denmark, Aarhus
Aarhus Universitet
Bögels, Susan Maria
Netherlands, Amsterdam
Universiteit Van Amsterdam
Cooper, Peter J.M.
United Kingdom, Reading
University of Reading
Creswell, Catharine S.
United Kingdom, Reading
University of Reading
Hartman, Catharina A.
Netherlands, Groningen
Rijksuniversiteit Groningen
Heiervang, Einar Røshol
Norway, Bergen
Haukeland Universitetssjukehus
Hötzel, Katrin
Germany, Bochum
Ruhr-universitat Bochum
In-Albon, Tina
Germany, Koblenz am Rhein
Universität Koblenz-landau
Lavallee, Kristen L.
Switzerland, Basel
Universitat Basel
Lyneham, Heidi J.
Australia, Macquarie Park
The Faculty of Medicine, Health and Human Sciences
Marin, Carla E.
United States, New Haven
Yale University
McKinnon, Anna Catherine
United Kingdom, Cambridge
Mrc Cognition and Brain Sciences Unit
Meiser-Stedman, Richard A.
United Kingdom, Cambridge
Mrc Cognition and Brain Sciences Unit
Morris, Talia M.
Australia, Macquarie Park
The Faculty of Medicine, Health and Human Sciences
Nauta, Maaike H.
Netherlands, Groningen
Rijksuniversiteit Groningen
Rapee, Ronald M.
Australia, Macquarie Park
The Faculty of Medicine, Health and Human Sciences
Schneider, Silvia
Germany, Bochum
Ruhr-universitat Bochum
Schneider, Sophie C.
Australia, Macquarie Park
The Faculty of Medicine, Health and Human Sciences
Silverman, Wendy K.
United States, New Haven
Yale University
Thastum, Mikael
Denmark, Aarhus
Aarhus Universitet
Thirlwall, Kerstin J.
United Kingdom, Reading
University of Reading
Waite, Polly
United Kingdom, Reading
University of Reading
Wergeland, Gro Janne H.
Norway, Bergen
Haukeland Universitetssjukehus
Lester, Kathryn J.
United Kingdom, Brighton
University of Sussex
Eley, Thalia C.
United Kingdom, London
Faculty of Life Sciences & Medicine
Statistics
Citations: 132
Authors: 30
Affiliations: 13
Identifiers
Doi:
10.1016/j.jaac.2015.03.018
ISSN:
08908567
Research Areas
Genetics And Genomics
Maternal And Child Health
Mental Health
Study Design
Cohort Study