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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed mice
Journal of Ethnopharmacology, Volume 74, No. 3, Year 2001
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Description
Previous studies realized in the laboratory have indicated that application of experimental stress (such as unavoidable footshock) induced significant behavioral, gastric and immunological alterations in mice. The aim of this study was to evaluate effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine on stress-induced behavioral, immunological and gastric alterations. Locomotor, postural and exploratory activities have been evaluated by two behavioral tests: light/dark box and staircase tests. Immunological studies were investigated to count white blood cells subpopulations (lymphocytes, neutrophils, monocytes and basophils) by coulter counter. The severity of gastric erosions was evaluated by microscopic technique in mice after experimental stress. The results have demonstrated that low doses of G. sempervirens L. and A. belladonna L. had a significant neurotropic and protective effects on behavioral and gastric alterations induced by experimental stress. The immunological protective effects observed were probably induced via their neurotropic effects. The P. histamine showed a significant immunoprotective and gastroprotective effect in mice exposed to experimental stress. Copyright © 2001 Elsevier Science Ireland Ltd.
Authors & Co-Authors
Bousta, Dalila
France, Nancy
Université de Lorraine
Soulimani, Rachid
France, Nancy
Université de Lorraine
Younos, Chaffique
France, Nancy
Université de Lorraine
Statistics
Citations: 53
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1016/S0378-8741(00)00346-9
ISSN:
03788741
Study Design
Exploratory Study